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Title: Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
Author: Liu, Xiling ; Somel, Mehmet ; Tang, Lin ; Yan, Zheng ; Jiang, Xi ; Guo, Song ; Yuan, Yuan ; He, Liu ; Oleksiak, Anna ; Zhang, Yan ; Li, Na ; Hu, Yuhui ; Chen, Wei ; null(仇子龙) ; Paeaebo, Svante ; Khaitovich, Philipp
Source: GENOME RESEARCH
Issued Date: 2012
Volume: 22, Issue:4, Pages:611-622
Keyword: HUMAN PREFRONTAL CORTEX ; NONHUMAN PRIMATE BRAINS ; LONG-TERM POTENTIATION ; CENTRAL-NERVOUS-SYSTEM ; HUMAN LIFE-HISTORY ; GENE-EXPRESSION ; TRANSCRIPTION FACTOR ; POSTSYNAPTIC DENSITY ; MAMMALIAN BRAINS ; CEREBRAL-CORTEX
Subject: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
Corresponding Author: Qiu, ZL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,zqlu@ion.ac.cn ; paabo@eva.mpg.de ; khaltovich@eva.mpg.de
English Abstract: Over the course of ontogenesis, the human brain and human cognitive abilities develop in parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used microarrays and RNA-sequencing to examine human-specific gene expression changes taking place during postnatal brain development in the prefrontal cortex and cerebellum of humans, chimpanzees, and rhesus macaques. We show that the most prominent human-specific expression change affects genes associated with synaptic functions and represents an extreme shift in the timing of synaptic development in the prefrontal cortex, but not the cerebellum. Consequently, peak expression of synaptic genes in the prefrontal cortex is shifted from <1 yr in chimpanzees and macaques to 5 yr in humans. This result was supported by protein expression profiles of synaptic density markers and by direct observation of synaptic density by electron microscopy. Mechanistically, the human-specific change in timing of synaptic development involves the MEF2A-mediated activity-dependent regulatory pathway. Evolutionarily, this change may have taken place after the split of the human and the Neanderthal lineages.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1494
Appears in Collections:神经所(总)_期刊论文
神经可塑性分子基础研究组_期刊论文

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Liu, Xiling; Somel, Mehmet; Tang, Lin; Yan, Zheng; Jiang, Xi; Guo, Song; Yuan, Yuan; He, Liu; Oleksiak, Anna; Zhang, Yan; Li, Na; Hu, Yuhui; Chen, Wei; Qiu, Zilong; Paeaebo, Svante; Khaitovich, Philipp.Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques,GENOME RESEARCH,2012,22(4):611-622
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