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Title: NeuroD2 regulates the development of hippocampal mossy fiber synapses
Author: Wilke, Scott A. ; Hall, Benjamin J. ; Antonios, Joseph K. ; DeNardo, Laura A. ; Otto, Stefanie ; Yuan, Bo ; Chen, Fading ; Robbins, Elissa M. ; Tiglio, Katie ; Williams, Megan E. ; null(仇子龙) ; Biederer, Thomas ; Ghosh, Anirvan
Source: NEURAL DEVELOPMENT
Issued Date: 2012
Volume: 7, Pages:41161
Keyword: ACTIVITY-DEPENDENT REGULATION ; MAGUK SCAFFOLDING PROTEINS ; LONG-TERM POTENTIATION ; SYNAPTIC PLASTICITY ; DENDRITIC SPINES ; IN-VIVO ; POSTNATAL-DEVELOPMENT ; RAT HIPPOCAMPUS ; CRITICAL PERIOD ; AMPA RECEPTORS
Subject: Developmental Biology ; Neurosciences & Neurology
Corresponding Author: Ghosh, A (reprint author), Univ Calif San Diego, Neurobiol Sect, Div Biol Sci, San Diego, CA 92093 USA,aghosh@ucsd.edu
English Abstract: Background: The assembly of neural circuits requires the concerted action of both genetically determined and activity-dependent mechanisms. Calcium-regulated transcription may link these processes, but the influence of specific transcription factors on the differentiation of synapse-specific properties is poorly understood. Here we characterize the influence of NeuroD2, a calcium-dependent transcription factor, in regulating the structural and functional maturation of the hippocampal mossy fiber (MF) synapse. Results: Using NeuroD2 null mice and in vivo lentivirus-mediated gene knockdown, we demonstrate a critical role for NeuroD2 in the formation of CA3 dendritic spines receiving MF inputs. We also use electrophysiological recordings from CA3 neurons while stimulating MF axons to show that NeuroD2 regulates the differentiation of functional properties at the MF synapse. Finally, we find that NeuroD2 regulates PSD95 expression in hippocampal neurons and that PSD95 loss of function in vivo reproduces CA3 neuron spine defects observed in NeuroD2 null mice. Conclusion: These experiments identify NeuroD2 as a key transcription factor that regulates the structural and functional differentiation of MF synapses in vivo.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1498
Appears in Collections:神经所(总)_期刊论文
神经可塑性分子基础研究组_期刊论文

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Wilke, Scott A.; Hall, Benjamin J.; Antonios, Joseph K.; DeNardo, Laura A.; Otto, Stefanie; Yuan, Bo; Chen, Fading; Robbins, Elissa M.; Tiglio, Katie; Williams, Megan E.; Qiu, Zilong; Biederer, Thomas; Ghosh, Anirvan.NeuroD2 regulates the development of hippocampal mossy fiber synapses,NEURAL DEVELOPMENT,2012,7():41161
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