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Title: Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization
Author: Guo, Shun-Ling ; Tan, Guo-He ; Li, Shuai ; Cheng, Xue-Wen ; Zhou, Ya ; Jia, Yun-Fang ; Xiong, Hui ; Tao, Jiong ; null(熊志奇)
Source: CELL RESEARCH
Issued Date: 2012
Volume: 22, Issue:2, Pages:387-398
Keyword: PLK2 ; morphogenesis ; BDNF ; ERK ; transcription ; POLO-LIKE KINASES ; INTEGRIN-BINDING PROTEIN ; LONG-TERM POTENTIATION ; BETA-CATENIN ; SYNAPTIC PLASTICITY ; HIPPOCAMPAL-NEURONS ; NEUROTROPHIC FACTOR ; SIGNALING PATHWAYS ; ALPHA-SYNUCLEIN ; NERVOUS-SYSTEM
Subject: Cell Biology
Corresponding Author: Xiong, ZQ (reprint author), Chinese Acad Sci, Inst Neurosci, Yueyang Rd 320,ION Bldg,Room 426, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn
English Abstract: Serum inducible kinase (SNK), also known as polo-like kinase 2 (PLK2), is a known regulator of mitosis, synaptogenesis and synaptic homeostasis. However, its role in early cortical development is unknown. Herein, we show that snk is expressed in the cortical plate from embryonic day 14, but not in the ventricular/subventricular zones (VZ/SVZ), and SNK protein localizes to the soma and dendrites of cultured immature cortical neurons. Loss of SNK impaired dendritic but not axonal arborization in a dose-dependent manner and overexpression had opposite effects, both in vitro and in vivo. Overexpression of SNK also caused abnormal branching of the leading process of migrating cortical neurons in electroporated cortices. The kinase activity was necessary for these effects. Extracellular signal-regulated kinase (ERK) pathway activity downstream of brain-derived neurotrophic factor (BDNF) stimulation led to increases in SNK protein expression via transcriptional regulation, and this upregulation was necessary for the growth-promoting effect of BDNF on dendritic arborization. Taken together, our results indicate that SNK is essential for dendrite morphogenesis in cortical neurons.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1504
Appears in Collections:神经所(总)_期刊论文
疾病神经生物学研究组_期刊论文

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Guo, Shun-Ling; Tan, Guo-He; Li, Shuai; Cheng, Xue-Wen; Zhou, Ya; Jia, Yun-Fang; Xiong, Hui; Tao, Jiong; Xiong, Zhi-Qi.Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization,CELL RESEARCH,2012,22(2):387-398
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