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Title: Lysosomal exocytosis in Schwann cells contributes to axon remyelination
Author: Chen, Gang ; Zhang, Zhijun ; Wei, Zhongya ; Cheng, Qiong ; Li, Xia ; Li, Wei ; Duan, Shumin ; Gu, Xiaosong
Source: GLIA
Issued Date: 2012
Volume: 60, Issue:2, Pages:295-305
Keyword: schwann cell ; lysosome ; exocytosis ; myelin ; MYELIN-ASSOCIATED GLYCOPROTEIN ; RAT PERIPHERAL-NERVE ; SECRETORY LYSOSOMES ; MESSENGER-RNA ; NEURAL CREST ; PROTEIN ; RAB27A ; REGENERATION ; DISORDERS ; LINEAGE
Subject: Neurosciences & Neurology
Corresponding Author: Chen, G (reprint author), Nantong Univ, Jiangsu Key Lab Neuroregenerat, Nantong 226001, Jiangsu, Peoples R China,chengang6626@ntu.edu.cn ; neurongu@public.nt.js.cn
English Abstract: Myelin biogenesis is a complex process involving coordinated exocytosis, endocytosis, mRNA transport, and cytoskeletal dynamics. Although abnormalities of myelin are common in lysosomal storage diseases, our understanding of the role of lysosomes in the formation and maintenance of myelin is still limited. Here, we show that late endosomes/lysosomes in Schwann cells contain abundant myelin protein P0, which accounts for over half the total protein of compact myelin in the peripheral nervous system and exhibit Ca2+-dependent exocytosis in response to various stimuli. Downregulation of Rab27a, a small GTPase required for the trafficking of the secretory lysosomes to the plasma membrane, largely blocked lysosomal exocytosis in Schwann cells and reduced the remyelination of regenerated sciatic nerve. These findings highlight a novel role for lysosomes in Schwann cells and suggest that the regulated lysosome exocytosis in Schwann cells may have important physiological and pathological significance in the peripheral nervous system. (c) 2011 Wiley Periodicals, Inc.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1507
Appears in Collections:神经所(总)_期刊论文

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Chen, Gang; Zhang, Zhijun; Wei, Zhongya; Cheng, Qiong; Li, Xia; Li, Wei; Duan, Shumin; Gu, Xiaosong.Lysosomal exocytosis in Schwann cells contributes to axon remyelination,GLIA,2012,60(2):295-305
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