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Title: The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling
Author: null(仇子龙) ; Sylwestrak, Emily L. ; Lieberman, David N. ; Zhang, Yan ; Liu, Xin-Yu ; Ghosh, Anirvan
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2012
Volume: 32, Issue:3, Pages:989-994
Keyword: CPG-BINDING PROTEIN-2 ; AMPA RECEPTOR ; HIPPOCAMPAL-NEURONS ; SUBUNIT ; EXPRESSION ; EXCITATION ; SYNAPSES ; GENE
Subject: Neurosciences & Neurology
Corresponding Author: Ghosh, A (reprint author), Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA,aghosh@ucsd.edu
English Abstract: Synaptic scaling is a form of homeostatic synaptic plasticity characterized by cell-wide changes in synaptic strength in response to changes in overall levels of neuronal activity. Here we report that bicuculline-induced increase in neuronal activity leads to a decrease in mEPSC amplitude and a decrease in expression of the AMPA receptor subunit GluR2 in rat hippocampal cultures. Bicuculline treatment also leads to an increase in the levels of the transcriptional repressor MeCP2, which binds to the GluR2 promoter along with the corepressors HDAC1 and mSin3A. Downregulation of MeCP2 by shRNA expression or genetic deletion blocks the bicuculline-induced decrease in GluR2 expression and mEPSC amplitude. These observations indicate that MeCP2 mediates activity-dependent synaptic scaling, and suggest that the pathophysiology of Rett syndrome, which is caused by mutations in MeCP2, may involve defects in activity-dependent regulation of synaptic currents.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1509
Appears in Collections:神经所(总)_期刊论文
神经可塑性分子基础研究组_期刊论文

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Recommended Citation:
Qiu, Zilong; Sylwestrak, Emily L.; Lieberman, David N.; Zhang, Yan; Liu, Xin-Yu; Ghosh, Anirvan.The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling,JOURNAL OF NEUROSCIENCE,2012,32(3):989-994
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