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Title: Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior
Author: Chen ZiJing ; null(王佐仁)
Source: SCIENCE CHINA-LIFE SCIENCES
Issued Date: 2012
Volume: 55, Issue:1, Pages:40946
Keyword: I-h channel ; Drosophila melanogaster ; HCN ; behavior ; ION CHANNELS ; PACEMAKER ; MELANOGASTER ; NEURONS ; INTEGRATION
Subject: Life Sciences & Biomedicine - Other Topics
Corresponding Author: Wang, ZR (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China,zuorenwang@ion.ac.cn
English Abstract: Hyperpolarization-activated, cyclic nucleotide-gated and cation-nonselective ion channels (I (h) channels, or HCN channels) are known to play important roles in mammals. Their physiological functions in invertebrate remain largely unclear. Here, we report our studies with I (h) channel in Drosophila melanogaster. Drosophila Ih channel mutants are found with several defects by behavioral analyses. Their lifespan is reduced, and their chemical sensitivity is shifted. In addition, their length of sleep at light-dark condition is mildly reduced. We generated transgenic flies of I (h) promoter-driven Gal4 and examined its expression pattern in both larvae and adult flies. Our results suggest that I (h) channel may play diverse roles in Drosophila and provide a basis to further expand our understanding of Drosophila Ih channel function in vivo.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1511
Appears in Collections:神经所(总)_期刊论文

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Chen ZiJing; Wang ZuoRen.Functional study of hyperpolarization activated channel (I-h) in Drosophila behavior,SCIENCE CHINA-LIFE SCIENCES,2012,55(1):40946
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