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Title: The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers
Author: Hou, Ying ; Zou, Qifei ; Ge, Ruiliang ; Shen, Feng ; null(王以政)
Source: CELL RESEARCH
Issued Date: 2012
Volume: 22, Issue:1, Pages:259-272
Keyword: tumor-initiating cells ; hepatocellular carcinoma ; metastasis ; HEPATOCELLULAR-CARCINOMA CELLS ; STEM-CELLS ; STEM/PROGENITOR CELLS ; PLASMINOGEN-ACTIVATOR ; CLINICAL-SIGNIFICANCE ; PROGENITOR CELLS ; EXPRESSION ; CD44 ; INVASION ; CD133
Subject: Cell Biology
Corresponding Author: Wang, YZ (reprint author), Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,shenfengdfgd@yahoo.com.cn ; yzwang@ion.ac.cn
English Abstract: Metastatic hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. However, the cell population responsible for its metastasis remains largely unknown. Here, we reported that CD133(+) CD44(+/high) defined a subgroup of tumor cells that was responsible for hematogenous metastasis of liver cancers. Immunohistochemical investigation of human HCC specimens revealed that the number of CD133(+) and CD44(+) HCC cells was increased and was associated with portal vein invasion. Purified CD133(+) or CD44(high) HCC cells were superior in clonogenic growth and vascular invasion, respectively. Thus, the combination of CD133 and CD44 was used to define a novel HCC sub-population. CD133(+) CD44(high), but not CD133(+) CD44(low/-), CD133-CD44(high) or CD133-CD44(low/-) xenografts, produced intrahepatic or lung metastasis in nude mice. Further analysis of human HCC samples by flow cytometry showed that the number of CD133(+) CD44(+) tumor cells was associated with portal vein metastasis. The cDNA microarray analysis of CD133(+) CD44(+) and CD133(+) CD44-tumor cells isolated from metastatic HCC patients revealed that these cells comprised of two different populations possessing distinct gene expression profiles. Our results suggest that CD133(+) CD44(+) tumor cells are a particular population responsible for hematogenous metastasis in liver cancers and that these cells might be targets for treatment of HCC metastasis.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1513
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Hou, Ying; Zou, Qifei; Ge, Ruiliang; Shen, Feng; Wang, Yizheng.The critical role of CD133(+)CD44(+/high) tumor cells in hematogenous metastasis of liver cancers,CELL RESEARCH,2012,22(1):259-272
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