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Title: Transient receptor potential canonical channels in angiogenesis and axon guidance
Author: Yu, Peng-chun ; Du, Jiu-lin
Source: CELLULAR AND MOLECULAR LIFE SCIENCES
Issued Date: 2011
Volume: 68, Issue:23, Pages:3815-3821
Keyword: TRPC ; Calcium ; Endothelial cells ; Growth cone ; Angiogenesis ; Axon guidance ; OPERATED CA2+ ENTRY ; NERVE GROWTH CONES ; TRP CHANNELS ; ENDOTHELIAL-CELLS ; INTRACELLULAR CALCIUM ; ION CHANNELS ; IN-VIVO ; CHEMOTROPIC GUIDANCE ; SIGNAL-TRANSDUCTION ; CAPSAICIN RECEPTOR
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Yu, PC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,chunpengyu@ion.ac.cn ; forestdu@ion.ac.cn
English Abstract: Wiring of vascular and neural networks requires precise guidance of growing blood vessels and axons, respectively, to reach their targets during development. Both of the processes share common molecular signaling pathways. Transient receptor potential canonical (TRPC) channels are calcium-permeable cation channels and gated via receptor- or store-operated mechanisms. Recent studies have revealed the requirement of TRPC channels in mediating guidance cue-induced calcium influx and their essential roles in regulating axon navigation and angiogenesis. Dissecting TRPC functions in these physiological processes may provide therapeutic implications for suppressing pathological angiogenesis and improving nerve regeneration.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1521
Appears in Collections:神经所(总)_期刊论文

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Yu, Peng-chun; Du, Jiu-lin.Transient receptor potential canonical channels in angiogenesis and axon guidance,CELLULAR AND MOLECULAR LIFE SCIENCES,2011,68(23):3815-3821
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