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Title: Short- and Long-Term Plasticity at the Axon Initial Segment
Author: Grubb, Matthew S. ; null(舒友生) ; Kuba, Hiroshi ; Rasband, Matthew N. ; Wimmer, Verena C. ; Bender, Kevin J.
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2011
Volume: 31, Issue:45, Pages:16049-16055
Keyword: ACTION-POTENTIAL INITIATION ; 5 PYRAMIDAL NEURONS ; SODIUM-CHANNELS ; CALCIUM-CHANNELS ; NERVOUS-SYSTEM ; GANGLION-CELLS ; KV1 CHANNELS ; ANKYRIN-G ; EXCITABILITY ; MECHANISM
Subject: Neurosciences & Neurology
Corresponding Author: Grubb, MS (reprint author), Kings Coll London, MRC Ctr Dev Neurobiol, London SE1 1UL, England,matthew.grubb@kcl.ac.uk ; kbender@gallo.ucsf.edu
English Abstract: The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of action potential initiation and the boundary between axonal and somatodendritic compartments. In recent years, our understanding of the molecular structure of the AIS, its maturation, and its multiple fundamental roles in neuronal function has seen major advances. We are beginning to appreciate that the AIS is dynamically regulated, both over short timescales via adaptations in ion channel function, and long timescales via activity-dependent structural reorganization. Here, we review results from this emerging field highlighting how structural and functional plasticity relate to the development of the initial segment, and to neuronal disorders linked to AIS dysfunction.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1524
Appears in Collections:神经所(总)_期刊论文
神经网络功能研究组_期刊论文

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Recommended Citation:
Grubb, Matthew S.; Shu, Yousheng; Kuba, Hiroshi; Rasband, Matthew N.; Wimmer, Verena C.; Bender, Kevin J..Short- and Long-Term Plasticity at the Axon Initial Segment,JOURNAL OF NEUROSCIENCE,2011,31(45):16049-16055
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