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Title: Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex
Author: Wang, Fei ; Zhu, Jun ; Zhu, Hong ; Zhang, Qi ; Lin, Zhanmin ; null(胡海岚)
Source: SCIENCE
Issued Date: 2011
Volume: 334, Issue:6056, Pages:693-697
Keyword: AMPA RECEPTOR TRAFFICKING ; DOMINANCE ; MICE ; PLASTICITY ; RATS ; ENVIRONMENT ; MODULATION ; BEHAVIOR ; MOUSE ; RAS
Subject: Science & Technology - Other Topics
Corresponding Author: Hu, HL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,hailan@ion.ac.cn
English Abstract: Dominance hierarchy has a profound impact on animals' survival, health, and reproductive success, but its neural circuit mechanism is virtually unknown. We found that dominance ranking in mice is transitive, relatively stable, and highly correlates among multiple behavior measures. Recording from layer V pyramidal neurons of the medial prefrontal cortex (mPFC) showed higher strength of excitatory synaptic inputs in mice with higher ranking, as compared with their subordinate cage mates. Furthermore, molecular manipulations that resulted in an increase and decrease in the synaptic efficacy in dorsal mPFC neurons caused an upward and downward movement in the social rank, respectively. These results provide direct evidence for mPFC's involvement in social hierarchy and suggest that social rank is plastic and can be tuned by altering synaptic strength in mPFC pyramidal cells.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1525
Appears in Collections:神经所(总)_期刊论文
神经环路与行为可塑性研究组_期刊论文

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Recommended Citation:
Wang, Fei; Zhu, Jun; Zhu, Hong; Zhang, Qi; Lin, Zhanmin; Hu, Hailan.Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex,SCIENCE,2011,334(6056):693-697
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