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Title: Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation
Author: Wang, Kaiyu ; Guo, Yanmeng ; Wang, Fei ; null(王佐仁)
Source: PLOS ONE
Issued Date: 2011
Volume: 6, Issue:11, Pages:e25890-e25891
Keyword: SEXUAL RECEPTIVITY ; SOCIAL EXPERIENCE ; MELANOGASTER ; PHEROMONE ; GENE ; NOCICEPTION ; AVOIDANCE ; TASTE ; FLY
Subject: Life Sciences & Biomedicine - Other Topics
Corresponding Author: Wang, KY (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Shanghai, Peoples R China,ZuorenWang@ion.ac.cn
English Abstract: The Drosophila melanogaster TRPA family member painless, expressed in a subset of multidendritic neurons embeding in the larval epidermis, is necessary for larval nociception of noxious heat or mechanical stimuli. However, the function of painless in adult flies remains largely unknown. Here we report that mutation of painless leads to a defect in male-male courtship behavior and alteration in olfaction sensitivity in adult flies. Specific downregulation of the expression of the Painless protein in the olfactory projection neurons (PNs) of the antennal lobes (ALs) resulted in a phenotype resembling that found in painless mutant flies, whereas overexpression of Painless in PNs of painless mutant males suppressed male-male courtship behavior. The downregulation of Painless exclusively during adulthood also resulted in male-male courtship behavior. In addition, mutation of the painless gene in flies caused changes in olfaction, suggesting a role for this gene in olfactory processing. These results indicate that functions of painless in the adult central nervous system of Drosophila include modulation of olfactory processing and inhibition of male-male courtship behavior.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1526
Appears in Collections:神经所(总)_期刊论文
神经环路与动物行为研究组_期刊论文

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Recommended Citation:
Wang, Kaiyu; Guo, Yanmeng; Wang, Fei; Wang, Zuoren.Drosophila TRPA Channel Painless Inhibits Male-Male Courtship Behavior through Modulating Olfactory Sensation,PLOS ONE,2011,6(11):e25890-e25891
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