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Title: Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization
Author: Wang, Tong ; Liu, Yang ; Xu, Xiao-Hui ; Deng, Cai-Yun ; Wu, Kong-Yan ; Zhu, Ji ; Fu, Xiu-Qing ; He, Miao ; null(罗振革)
Source: DEVELOPMENTAL CELL
Issued Date: 2011
Volume: 21, Issue:3, Pages:431-444
Keyword: LETHAL-GIANT-LARVAE ; NEURITE OUTGROWTH ; PLASMA-MEMBRANE ; GLUT4 TRANSLOCATION ; HIPPOCAMPAL-NEURONS ; EXOCYST COMPLEX ; MUSCLE-CELLS ; SAD KINASES ; POLARITY ; GTPASES
Subject: Cell Biology ; Developmental Biology
Corresponding Author: Luo, ZG (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,zgluo@ion.ac.cn
English Abstract: Directed membrane trafficking is believed to be crucial for axon development during neuronal morphogenesis. However, the underlying mechanisms are poorly understood. Here, we report a role of Lgl1, the mammalian homolog of Drosophila tumor suppressor Lethal giant larvae, in controlling membrane trafficking underlying axonal growth. We find that Lgl1 is associated with plasmalemmal precursor vesicles and enriched in developing axons. Lgl1 upregulation promoted axonal growth, whereas downregulation attenuated it as well as directional membrane insertion. Interestingly, Lgl1 interacted with and activated Rab10, a small GTPase that mediates membrane protein trafficking, by releasing GDP dissociation inhibitor (GDI) from Rab10. Furthermore, Rab10 lies downstream of Lgl1 in axon development and directional membrane insertion. Finally, both Lgl1 and Rab10 are required for neocortical neuronal polarization in vivo. Thus, the Lgl1 regulation of Rab10 stimulates the trafficking of membrane precursor vesicles, whose fusion with the plasmalemma is crucial for axonal growth.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1527
Appears in Collections:神经所(总)_期刊论文
突触信号研究组_期刊论文

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Recommended Citation:
Wang, Tong; Liu, Yang; Xu, Xiao-Hui; Deng, Cai-Yun; Wu, Kong-Yan; Zhu, Ji; Fu, Xiu-Qing; He, Miao; Luo, Zhen-Ge.Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization,DEVELOPMENTAL CELL,2011,21(3):431-444
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