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Title: Tools for studying the role of N-cadherin mediated extracellular interaction in neuronal development and function
Author: Yu, Xiang
Source: CELL ADHESION & MIGRATION
Issued Date: 2011
Volume: 5, Issue:3, Pages:227-231
Keyword: N-cadherin ; dendrite development ; neuronal activity ; homophilic interaction ; cell-cell contact ; activity-independent expression vector ; CELL-ADHESION MOLECULES ; HIPPOCAMPAL-NEURONS ; NEURITE OUTGROWTH ; FAMILY ; SYNAPTOGENESIS ; SPECIFICITY ; EXPRESSION ; CATENINS
Subject: Cell Biology
Corresponding Author: Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,yuxiang@ion.ac.cn
English Abstract: N-cadherin is a homophilic cell adhesion molecule that plays important roles in many aspects of neuronal development. In order to better understand the function of N-cadherin mediated cell-cell contact in activity-dependent dendrite development, we generated a number of new tools. EC1, consisting of the first extracellular domain of N-cadherin, can specifically inhibit N-cadherin, but not E-cadherin, mediated cell-cell contact, both when overexpressed in neurons and added as a purified protein. Ncad-HA is an extracellularly epitope-tagged version of N-cadherin that, when overexpressed under the activity-independent pCS2min promoter, can be used to assay surface N-cadherin level following various manipulations. These tools are likely to be very useful for studying the function of N-cadherin in multiple aspects of neural circuit development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1539
Appears in Collections:神经所(总)_期刊论文
树突发育与神经环路形成研究组_期刊论文

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Yu, Xiang.Tools for studying the role of N-cadherin mediated extracellular interaction in neuronal development and function,CELL ADHESION & MIGRATION,2011,5(3):227-231
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