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Title: MiR-125b targets BCL3 and suppresses ovarian cancer proliferation
Author: Guan, Yi ; Yao, Hailan ; Zheng, Zhihong ; Qiu, Guangrong ; Sun, Kailai
Source: INTERNATIONAL JOURNAL OF CANCER
Issued Date: 2011
Volume: 128, Issue:10, Pages:2274-2283
Keyword: miR-125b ; ovarian cancer ; proliferation ; BCL3 ; MICRORNA EXPRESSION PROFILES ; CELL-PROLIFERATION ; SURVIVAL ; STIMULATION ; MALIGNANCY ; RESISTANCE ; APOPTOSIS ; ROLES
Subject: Oncology
Corresponding Author: Sun, KL (reprint author), China Med Univ, Dept Med Genet, Shenyang 110001, Peoples R China,klsun@mail.cmu.edu.cn
English Abstract: Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal formation. This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene, BCL3. Furthermore, expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1541
Appears in Collections:神经所(总)_期刊论文

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Guan, Yi; Yao, Hailan; Zheng, Zhihong; Qiu, Guangrong; Sun, Kailai.MiR-125b targets BCL3 and suppresses ovarian cancer proliferation,INTERNATIONAL JOURNAL OF CANCER,2011,128(10):2274-2283
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