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Title: Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase
Author: Li, Kai-Cheng ; Zhang, Fang-Xiong ; Li, Chang-Lin ; Wang, Feng ; Yu, Ming-Yan ; Zhong, Yan-Qing ; Zhang, Kai-Hua ; Lu, Ying-Jin ; Wang, Qiong ; Ma, Xiao-Li ; Yao, Jun-Ru ; Wang, Jin-Yuan ; Lin, Li-Bo ; Han, Mei ; Zhang, Yu-Qiu ; Kuner, Rohini ; Xiao, Hua-Sheng ; Bao, Lan ; Gao, Xiang ; null(张 旭)
Source: NEURON
Issued Date: 2011
Volume: 69, Issue:5, Pages:974-987
Keyword: DORSAL-ROOT GANGLIA ; PERIPHERAL NERVOUS-SYSTEM ; SYNAPTIC VESICLE ; SPINAL-CORD ; NA+/K+ PUMP ; NEURONS ; RAT ; PROTEIN ; EXPRESSION ; ISOFORMS
Subject: Neurosciences & Neurology
Corresponding Author: Gao, XA (reprint author), Nanjing Univ, Model Anim Res Ctr, Nanjing 210061, Peoples R China,gaoxiang@nju.edu.cn ; xu.zhang@ion.ac.cn
English Abstract: Excitatory synaptic transmission is modulated by inhibitory neurotransmitters and neuromodulators. We found that the synaptic transmission of somatic sensory afferents can be rapidly regulated by a presynaptically secreted protein, follistatin-like 1 (FSTL1), which serves as a direct activator of Na+,K+-ATPase (NKA). The FSTL1 protein is highly expressed in small-diameter neurons of the dorsal root ganglion (DRG). It is transported to axon terminals via small translucent vesicles and secreted in both spontaneous and depolarization-induced manners. Biochemical assays showed that FSTL1 binds to the alpha 1 subunit of NKA and elevates NKA activity. Extracellular FSTL1 induced membrane hyperpolarization in cultured cells and inhibited afferent synaptic transmission in spinal cord slices by activating NKA. Genetic deletion of FSTL1 in small DRG neurons of mice resulted in enhanced afferent synaptic transmission and sensory hypersensitivity, which could be reduced by intrathecally applied FSTL1 protein. Thus, FSTL1-dependent activation of NKA regulates the threshold of somatic sensation.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1547
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Li, Kai-Cheng; Zhang, Fang-Xiong; Li, Chang-Lin; Wang, Feng; Yu, Ming-Yan; Zhong, Yan-Qing; Zhang, Kai-Hua; Lu, Ying-Jin; Wang, Qiong; Ma, Xiao-Li; Yao, Jun-Ru; Wang, Jin-Yuan; Lin, Li-Bo; Han, Mei; Zhang, Yu-Qiu; Kuner, Rohini; Xiao, Hua-Sheng; Bao, Lan; Gao, Xiang; Zhang, Xu.Follistatin-like 1 Suppresses Sensory Afferent Transmission by Activating Na+,K+-ATPase,NEURON,2011,69(5):974-987
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