中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation
Author: He, Shao-Qiu ; Zhang, Zhen-Ning ; Guan, Ji-Song ; Liu, Hong-Rui ; Zhao, Bo ; Wang, Hai-Bo ; Li, Qian ; Yang, Hong ; Luo, Jie ; Li, Zi-Yan ; Wang, Qiong ; Lu, Ying-Jin ; Bao, Lan ; null(张 旭)
Source: NEURON
Issued Date: 2011
Volume: 69, Issue:1, Pages:120-131
Keyword: DORSAL-ROOT GANGLIA ; PROTEIN-COUPLED RECEPTORS ; NOXIOUS THERMAL STIMULI ; RAT SPINAL-CORD ; KNOCK-OUT MICE ; DOWN-REGULATION ; PHYSICAL-DEPENDENCE ; MORPHINE ANALGESIA ; SUBSTANCE-P ; TOLERANCE
Subject: Neurosciences & Neurology
Corresponding Author: Bao, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China,baolan@sibs.ac.cn ; xu.zhang@ion.ac.cn
English Abstract: delta-opioid receptors (DORs) form heteromers with mu-opioid receptors (MORs) and negatively regulate MOR-mediated spinal analgesia. However, the underlying mechanism remains largely unclear. The present study shows that the activity of MORs can be enhanced by preventing MORs from DOR-mediated codegradation. Treatment with DOR-specific agonists led to endocytosis of both DORs and MORs. These receptors were further processed for ubiquitination and lysosomal degradation, resulting in a reduction of surface MORs. Such effects were attenuated by treatment with an interfering peptide containing the first transmembrane domain of MOR (MOR(Tm1)), which interacted with DORs and disrupted the MOR/DOR interaction. Furthermore, the systemically applied fusion protein consisting of MOR(TM1) and TAT at the C terminus could disrupt the MOR/DOR interaction in the mouse spinal cord, enhance the morphine analgesia, and reduce the antinociceptive tolerance to morphine. Thus, dissociation of MORs from DORs in the cell membrane is a potential strategy to improve opioid analgesic therapies.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1558
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
He-2011-Facilitation of mu-O.pdf(1702KB)----开放获取View Download

Recommended Citation:
He, Shao-Qiu; Zhang, Zhen-Ning; Guan, Ji-Song; Liu, Hong-Rui; Zhao, Bo; Wang, Hai-Bo; Li, Qian; Yang, Hong; Luo, Jie; Li, Zi-Yan; Wang, Qiong; Lu, Ying-Jin; Bao, Lan; Zhang, Xu.Facilitation of mu-Opioid Receptor Activity by Preventing delta-Opioid Receptor-Mediated Codegradation,NEURON,2011,69(1):120-131
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[He, Shao-Qiu]'s Articles
[Zhang, Zhen-Ning]'s Articles
[Guan, Ji-Song]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[He, Shao-Qiu]‘s Articles
[Zhang, Zhen-Ning]‘s Articles
[Guan, Ji-Song]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: He-2011-Facilitation of mu-O.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!