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Title: Expression of Ventral Diencephalon-Enriched Genes in Zebrafish
Author: Li, Sen ; Yin, Min ; Liu, Shuxi ; Chen, Yi ; Yin, Yanqing ; Liu, Tingxi ; null(周嘉伟)
Source: DEVELOPMENTAL DYNAMICS
Issued Date: 2010
Volume: 239, Issue:12, Pages:3368-3379
Keyword: dopaminergic neuron ; diencephalon ; Id3 ; maturation ; MIDBRAIN DOPAMINERGIC-NEURONS ; TRANSCRIPTION FACTOR KLF7 ; CELL FATE ; NURR1 ; SURVIVAL ; ID3 ; DIFFERENTIATION ; NEUROGENESIS ; PROTEIN ; SYSTEM
Subject: Anatomy & Morphology ; Developmental Biology
Corresponding Author: Zhou, JW (reprint author), Chinese Acad Sci, Inst Neurosci, State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,jwzhou@ion.ac.cn
English Abstract: Dopaminergic (DA) neurons in the vertebrate di- and mesencephalon play essential roles in movement control, endocrine modulation and many other important physiological activities. To identify genes that may regulate the specification and differentiation of diencephalic DA neurons in zebrafish, the spatial and temporal expression pattern of a set of genes was investigated. In situ hybridization analysis revealed that expression of DNA binding inhibitor 3 (Id3), early B cell factor 2 (Ebf2), Ebf3, Iroquois related homeobox 1 (Irx1), Kruppel-like factor 7 (Klf7), mab-21-like 1 (Mab21l1), fatty acid binding protein 7 (Fabp7) and stathmin-like 4 (Stmn4), were enriched in the diencephalon of zebrafish. Among these genes, Id3 was expressed specifically in a subset of DA neurons in the ventral diencephalon, with co-expression of neurogenin1 (Ngn1). Alteration of expression levels of Id3 inhibited maturation of developing DA neurons. Taken together, our study provides genetic characteristics of DA neurons in the diencephalon of zebrafish. Developmental Dynamics 239:3368-3379, 2010. (C) 2010 Wiley-Liss, Inc.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1563
Appears in Collections:神经所(总)_期刊论文
基底神经节的发育与退行性疾病研究组_期刊论文

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Li, Sen; Yin, Min; Liu, Shuxi; Chen, Yi; Yin, Yanqing; Liu, Tingxi; Zhou, Jiawei.Expression of Ventral Diencephalon-Enriched Genes in Zebrafish,DEVELOPMENTAL DYNAMICS,2010,239(12):3368-3379
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