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Title: Effects of low level of methylmercury on proliferation of cortical progenitor cells
Author: Xu, Mingyu ; Yan, Chonghuai ; Tian, Ying ; Yuan, Xiaobing ; Shen, Xiaoming
Source: BRAIN RESEARCH
Issued Date: 2010
Volume: 1359, Issue:pt 1, Pages:272-280
Keyword: Methylmercury ; Neural progenitor cells ; Proliferation ; Cyclin E ; NEURAL STEM-CELLS ; DEVELOPMENTAL EXPOSURE ; CYCLE PROGRESSION ; MERCURY EXPOSURE ; DEVELOPING BRAIN ; RAT-BRAIN ; G1 PHASE ; NEUROGENESIS ; TOXICITY ; DIFFERENTIATION
Subject: Neurosciences & Neurology
Corresponding Author: Shen, XM (reprint author), Shanghai Jiao Tong Univ, XinHua Hosp, Sch Med,Shanghai Inst Pediat Res, Shanghai Key Lab Childrens Environm Hlth, Shanghai 200092, Peoples R China,xmshen@shsmu.edu.cn
English Abstract: Methylmercury (MeHg) is a potent environmental neurotoxin that shows toxicity to developing central nervous system (CNS), causing brain damage in children even at low exposure levels. However, the mechanisms for its effect on CNS are not well understood. In current study, primary cultures of progenitor cells from embryonic cerebral cortex were used as a model system to study the potential effect and the underlying mechanism of MeHg on neural progenitor cells. Results showed that, in cultured cortical progenitor cells, 48-h exposure to low-level of MeHg (at 2.5 nM, 5 nM and 50 nM, respectively) caused G1/S cell cycle arrest in a dose-dependent manner without inducing cell death. Interestingly, the expression of cyclin E, which promotes G1/S transition, but not cyclin D1 and CDK2, was selectively downregulated by exposure of MeHg. In addition, low-level of MeHg inhibited the maintenance of ERK1/2 phosphorylation, possibly by abolishing the late phase ERK1/2 activation induced by bFGF. Thus, MeHg may induce proliferation inhibition and cell cycle arrest of neural progenitor cells via regulating cyclin E expression and perturbing a pathway that involves ERK1/2. (C) 2010 Elsevier B.V. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1566
Appears in Collections:神经所(总)_期刊论文

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Xu, Mingyu; Yan, Chonghuai; Tian, Ying; Yuan, Xiaobing; Shen, Xiaoming.Effects of low level of methylmercury on proliferation of cortical progenitor cells,BRAIN RESEARCH,2010,1359():272-280
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