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Title: Nestin is essential for mitogen-stimulated proliferation of neural progenitor cells
Author: Xue, Xiao-jing ; Yuan, Xiao-bing
Source: MOLECULAR AND CELLULAR NEUROSCIENCE
Issued Date: 2010
Volume: 45, Issue:1, Pages:26-36
Keyword: Nestin ; Neural progenitor cells ; Proliferation ; PI3K ; siRNA ; INTERMEDIATE-FILAMENT PROTEIN ; EPIDERMAL-GROWTH-FACTOR ; CENTRAL-NERVOUS-SYSTEM ; STEM-CELLS ; SUBVENTRICULAR ZONE ; NEUROEPITHELIAL CELLS ; RADIAL MIGRATION ; CEREBRAL-CORTEX ; EXPRESSION ; NEUROGENESIS
Subject: Neurosciences & Neurology
Corresponding Author: Yuan, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,yuanxb@ion.ac.cn
English Abstract: The intermediate filament (IF) protein nestin is a widely accepted molecular marker for neural progenitor cells (NPCs), but its function during neurogenesis remains largely unknown. We found that in embryonic cortical NPCs down-regulation of the expression of nestin, but not its co-polymer IF protein vimentin, resulted in a G1 cell-cycle arrest and a severe reduction in the generation of neurons. Furthermore, down-regulating nestin expression in cultured cortical NPCs markedly suppressed their colony-formation ability and blocked the elevation of the cyclin D1/E protein level in response to the treatment with bFGF. Interestingly, nestin down-regulation caused a marked suppression in the activation of the phosphoinositide 3-kinase (PI3K) pathway but not the mitogen-activated protein kinase (MAPK) pathway in these NPCs. Moreover, defects in the proliferation of cortical NPCs caused by nestin down-regulation could be prevented by up-regulating PI3K activity. Thus, nestin is essential for the proliferation of NPCs by promoting the activation of PI3K in response to mitogenic growth factors. (C) 2010 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1578
Appears in Collections:神经所(总)_期刊论文

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Xue, Xiao-jing; Yuan, Xiao-bing.Nestin is essential for mitogen-stimulated proliferation of neural progenitor cells,MOLECULAR AND CELLULAR NEUROSCIENCE,2010,45(1):26-36
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