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Title: Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation
Author: Xu, Tian-Le(徐天乐) ; Gong, Neng
Source: PROGRESS IN NEUROBIOLOGY
Issued Date: 2010
Volume: 91, Issue:4, Pages:349-361
Keyword: Glycine ; Glycine receptor ; NMDA receptor ; Hippocampus ; Homeostatic regulation ; DORSAL COMMISSURAL NEURONS ; D-ASPARTATE RECEPTOR ; PROTEIN-KINASE-C ; ACTIVATED CHLORIDE CURRENTS ; TRANSPORTER SUBTYPE 1B ; SUBUNIT MESSENGER-RNAS ; SPINAL-CORD NEURONS ; RAT HIPPOCAMPAL ; NMDA RECEPTOR ; D-SERINE
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: Glycine is a primary inhibitory neurotransmitter in the spinal cord and brainstem. It acts at glycine receptor (GlyR)-chloride channels, as well as a co-agonist of NMDA receptors (NMDARs). In the hippocampus, the study of GlyRs has largely been under-appreciated due to the apparent absence of glycinergic synaptic transmission. Emerging evidence has shown the presence of extrasynaptic GlyRs in the hippocampus, which exert a tonic inhibitory role, and can be highly regulated under many pathophysiological conditions. On the other hand, besides D-serine, glycine has also been shown to modulate NMDAR function in the hippocampus. The simultaneous activation of excitatory NMDARs and inhibitory GlyRs may provide a homeostatic regulation of hippocampal network function. Furthermore, glycine can regulate hippocampal neuronal activity through GlyR-mediated cross-inhibition of GABAergic inhibition, or through the glycine binding site-dependent internalization of NMDARs. Therefore, hippocampal glycine and its receptors may operate in concert to finely regulate hippocampus-dependent high brain function such as learning and memory. Finally, dysfunction of hippocampal glycine signaling is associated with neuropsychiatric disorders. We speculate that further studies of hippocampal glycine-mediated regulation may help develop novel glycine-based approaches for therapeutic developments. (C) 2010 Elsevier Ltd. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1583
Appears in Collections:神经所(总)_期刊论文

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Xu, Tian-Le; Gong, Neng.Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation,PROGRESS IN NEUROBIOLOGY,2010,91(4):349-361
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