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Title: Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons
Author: Wang, Hai-Bo ; Zhao, Bo ; Zhong, Yan-Qing ; Li, Kai-Cheng ; Li, Zi-Yan ; Wang, Qiong ; Lu, Yin-Jing ; Zhang, Zhen-Ning ; He, Shao-Qiu ; Zheng, Han-Cheng ; Wu, Sheng-Xi ; Hokfelt, Tomas G. M. ; Bao, Lan ; null(张 旭)
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Issued Date: 2010
Volume: 107, Issue:29, Pages:13117-13122
Keyword: dorsal root ganglion ; spinal cord ; peptides ; pain ; tolerance ; DORSAL-ROOT GANGLIA ; RAT SPINAL-CORD ; AUTORADIOGRAPHIC LOCALIZATION ; MORPHINE-TOLERANCE ; MESSENGER-RNAS ; MICE ; EXPRESSION ; ANALGESIA ; HORN ; HETERODIMERIZATION
Subject: Science & Technology - Other Topics
Corresponding Author: Hokfelt, TGM (reprint author), Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden,tomas.hokfelt@ki.se ; baolan@sibs.ac.cn ; xu.zhang@ion.ac.cn
English Abstract: Morphine-induced analgesia and antinociceptive tolerance are known to be modulated by interaction between delta-opioid receptors (DORs) and mu-opioid receptors (MORs) in the pain pathway. However, evidence for expression of DORs in nociceptive small-diameter neurons in dorsal root ganglia (DRG) and for coexistence of DORs with MORs and neuropeptides has recently been challenged. We now report, using in situ hybridization, single-cell PCR, and immunostaining, that DORs are widely expressed not only in large DRG neurons but in small ones and coexist with MORs in peptidergic small DRG neurons, with protachykinin-dependent localization in large dense-core vesicles. Importantly, both DOR and MOR agonists reduce depolarization-induced Ca(2+) currents in single small DRG neurons and inhibit afferent C-fiber synaptic transmission in the dorsal spinal cord. Thus, coexistence of DORs and MORs in small DRG neurons is a basis for direct interaction of opioid receptors in modulation of nociceptive afferent transmission and opioid analgesia.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1585
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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Recommended Citation:
Wang, Hai-Bo; Zhao, Bo; Zhong, Yan-Qing; Li, Kai-Cheng; Li, Zi-Yan; Wang, Qiong; Lu, Yin-Jing; Zhang, Zhen-Ning; He, Shao-Qiu; Zheng, Han-Cheng; Wu, Sheng-Xi; Hokfelt, Tomas G. M.; Bao, Lan; Zhang, Xu.Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(29):13117-13122
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