中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons
Author: Li, Ning ; Zhao, Chun-Tao ; Wang, Ying ; Yuan, Xiao-Bing
Source: PLOS ONE
Issued Date: 2010
Volume: 5, Issue:5, Pages:e10596-e10597
Keyword: CCAAT DISPLACEMENT PROTEIN ; CELL-CYCLE EXIT ; HOMEODOMAIN PROTEIN ; HOMEOBOX GENE ; CEREBRAL-CORTEX ; RHO-GTPASES ; P27(KIP1) EXPRESSION ; SUBVENTRICULAR ZONE ; TRANSGENIC MICE ; DROSOPHILA CUT
Subject: Life Sciences & Biomedicine - Other Topics
Corresponding Author: Li, N (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,yuanxb@ion.ac.cn
English Abstract: In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27(Kip1), and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1593
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
journal.pone.0010596.pdf(1379KB)----开放获取View Download

Recommended Citation:
Li, Ning; Zhao, Chun-Tao; Wang, Ying; Yuan, Xiao-Bing.The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons,PLOS ONE,2010,5(5):e10596-e10597
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Ning]'s Articles
[Zhao, Chun-Tao]'s Articles
[Wang, Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Ning]‘s Articles
[Zhao, Chun-Tao]‘s Articles
[Wang, Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: journal.pone.0010596.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!