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Title: Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons
Author: He, Shao-Qiu ; Yao, Jun-Ru ; Zhang, Fang-Xiong ; Wang, Qiong ; Bao, Lan ; null(张 旭)
Source: MOLECULAR PAIN
Issued Date: 2010
Volume: 6, Pages:23-23
Keyword: NECROSIS-FACTOR-ALPHA ; DORSAL-ROOT GANGLION ; PRIMARY AFFERENT NEURONS ; CHROMOSOMAL LOCALIZATION ; NEUROPATHIC PAIN ; TNF-ALPHA ; PERIPHERAL INFLAMMATION ; BOWEL-DISEASE ; SCIATIC-NERVE ; GROWTH-FACTOR
Subject: Neurosciences & Neurology
Corresponding Author: Zhang, X (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xu.zhang@ion.ac.cn
English Abstract: Pancreatitis-associated protein (PAP)-I and -II, lectin-related secretory proteins, are members of the regenerating gene (Reg) family. Although expression of PAP-I was found in the dorsal root ganglion (DRG) neurons following peripheral nerve injury and cystitis, whether PAP-II could be expressed in DRG neurons in chronic pain models remains unclear. The present study shows an inflammation-and nerve injury-triggered expression of PAP-II in rat DRG neurons. In situ hybridization showed that only a few DRG neurons normally contained PAP-I and -II mRNAs. After peripheral inflammation, PAP-I and -II mRNAs were present in over half of small DRG neurons. Such an elevated expression of PAPI and -II reached the peak level on the second day. Immunostaining showed that the expression of PAP-II was mostly increased in the isolectin B4-positive subset of small DRG neurons after inflammation. Furthermore, the expression of PAP-II was also induced in DRG neurons after peripheral nerve injury. Interestingly, PAP-II expression was shifted from small neurons on day 2 to large DRG neurons that expressed neuropeptide Y during the later post-injury days. These results suggest that PAP-II may play potential roles in the modulation of spinal sensory pathways in pathological pain states.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1597
Appears in Collections:神经所(总)_期刊论文
感觉系统研究组_期刊论文

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He, Shao-Qiu; Yao, Jun-Ru; Zhang, Fang-Xiong; Wang, Qiong; Bao, Lan; Zhang, Xu.Inflammation and nerve injury induce expression of pancreatitis-associated protein-II in primary sensory neurons,MOLECULAR PAIN,2010,6():23-23
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