中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer Pain
Author: Tong, Zhiqian ; Luo, Wenhong ; Wang, Yanqing ; Yang, Fei ; Han, Ying ; Li, Hui ; Luo, Hongjun ; Duan, Bo ; Xu, Tianle(徐天乐) ; Maoying, Qiliang ; Tan, Huangying ; Wang, Jun ; Zhao, Hongmei ; Liu, Fengyu ; Wan, You
Source: PLOS ONE
Issued Date: 2010
Volume: 5, Issue:4, Pages:e10234-e10235
Keyword: DORSAL-ROOT GANGLION ; COMPLETE FREUNDS-ADJUVANT ; ISOLATED RAT HEPATOCYTES ; HUMAN OSTEOBLASTIC CELLS ; BREAST-CANCER ; CAPSAICIN RECEPTOR ; ION-CHANNEL ; GLUTATHIONE ; EXPRESSION ; MELATONIN
Subject: Life Sciences & Biomedicine - Other Topics
Corresponding Author: Tong, ZQ (reprint author), Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China,tzq88666883@sina.com
English Abstract: Background: There is current interest in understanding the molecular mechanisms of tumor-induced bone pain. Accumulated evidence shows that endogenous formaldehyde concentrations are elevated in the blood or urine of patients with breast, prostate or bladder cancer. These cancers are frequently associated with cancer pain especially after bone metastasis. It is well known that transient receptor potential vanilloid receptor 1 (TRPV1) participates in cancer pain. The present study aims to demonstrate that the tumor tissue-derived endogenous formaldehyde induces bone cancer pain via TRPV1 activation under tumor acidic environment. Methodology/Principal Findings: Endogenous formaldehyde concentration increased significantly in the cultured breast cancer cell lines in vitro, in the bone marrow of breast MRMT-1 bone cancer pain model in rats and in tissues from breast cancer and lung cancer patients in vivo. Low concentrations (1 similar to 5 mM) of formaldehyde induced pain responses in rat via TRPV1 and this pain response could be significantly enhanced by pH 6.0 (mimicking the acidic tumor microenvironment). Formaldehyde at low concentrations (1 mM to 100 mM) induced a concentration-dependent increase of [Ca(2+)]i in the freshly isolated rat dorsal root ganglion neurons and TRPV1-transfected CHO cells. Furthermore, electrophysiological experiments showed that low concentration formaldehyde-elicited TRPV1 currents could be significantly potentiated by low pH (6.0). TRPV1 antagonists and formaldehyde scavengers attenuated bone cancer pain responses. Conclusions/Significance: Our data suggest that cancer tissues directly secrete endogenous formaldehyde, and this formaldehyde at low concentration induces metastatic bone cancer pain through TRPV1 activation especially under tumor acidic environment.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1598
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
journal.pone.0010234.pdf(1114KB)----开放获取View Download

Recommended Citation:
Tong, Zhiqian; Luo, Wenhong; Wang, Yanqing; Yang, Fei; Han, Ying; Li, Hui; Luo, Hongjun; Duan, Bo; Xu, Tianle; Maoying, Qiliang; Tan, Huangying; Wang, Jun; Zhao, Hongmei; Liu, Fengyu; Wan, You.Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer Pain,PLOS ONE,2010,5(4):e10234-e10235
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tong, Zhiqian]'s Articles
[Luo, Wenhong]'s Articles
[Wang, Yanqing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tong, Zhiqian]‘s Articles
[Luo, Wenhong]‘s Articles
[Wang, Yanqing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: journal.pone.0010234.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!