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Title: Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons
Author: Ji, Yuanyuan ; Lu, Yuan ; Yang, Feng ; Shen, Wanhua ; Tang, Tina Tze-Tsang ; Feng, Linyin ; Duan, Shumin ; Lu, Bai
Source: NATURE NEUROSCIENCE
Issued Date: 2010
Volume: 13, Issue:3, Pages:302-U7
Keyword: NERVE GROWTH-FACTOR ; HIGH-FREQUENCY STIMULATION ; NEUROTROPHIC FACTOR BDNF ; LONG-TERM POTENTIATION ; SYNAPTIC-TRANSMISSION ; HIPPOCAMPAL-NEURONS ; DIFFERENTIAL REGULATION ; KINASE ACTIVATION ; ADULT HIPPOCAMPUS ; PC12 CELLS
Subject: Neurosciences & Neurology
Corresponding Author: Lu, B (reprint author), GlaxoSmithKline Inc, R&D China, Shanghai, Peoples R China,bai.b.lu@gsk.com
English Abstract: Extracellular factors may act on cells in two distinct modes: an acute increase in concentration as a result of regulated secretion, or a gradual increase in concentration when secreted constitutively or from a distant source. We found that cellular responses to brain-derived neurotrophic factor ( BDNF) differed markedly depending on how BDNF was delivered. In cultured rat hippocampal neurons, acute and gradual increases in BDNF elicited transient and sustained activation of TrkB receptor and its downstream signaling, respectively, leading to differential expression of Homer1 and Arc. Transient TrkB activation promoted neurite elongation and spine head enlargement, whereas sustained TrkB activation facilitated neurite branch and spine neck elongation. In hippocampal slices, fast and slow increases in BDNF enhanced basal synaptic transmission and LTP, respectively. Thus, the kinetics of TrkB activation is critical for cell signaling and functions. This temporal dimension in cellular signaling may also have implications for the therapeutic drug design.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1603
Appears in Collections:神经所(总)_期刊论文

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Ji, Yuanyuan; Lu, Yuan; Yang, Feng; Shen, Wanhua; Tang, Tina Tze-Tsang; Feng, Linyin; Duan, Shumin; Lu, Bai.Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons,NATURE NEUROSCIENCE,2010,13(3):302-U7
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