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Title: Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex
Author: Ye, Chang-quan ; null(蒲慕明) ; Dan, Yang ; Zhang, Xiao-hui
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2010
Volume: 30, Issue:5, Pages:1861-1868
Keyword: FREQUENCY-MODULATED SWEEPS ; PRIMARY VISUAL-CORTEX ; ECHO-LOCATING BATS ; INFERIOR COLLICULUS ; UNDERLYING SELECTIVITY ; RECEPTIVE-FIELDS ; SIMPLE CELLS ; COMMUNICATION SOUNDS ; STIMULUS SELECTIVITY ; BALANCED INHIBITION
Subject: Neurosciences & Neurology
Corresponding Author: Dan, Y (reprint author), Univ Calif Berkeley, Dept Cell & Mol Biol, Div Neurobiol, Berkeley, CA 94720 USA,ydan@berkeley.edu ; xhzhang@ion.ac.cn
English Abstract: Frequency modulation (FM) is a prominent feature in animal vocalization and human speech. Although many neurons in the auditory cortex are known to be selective for FM direction, the synaptic mechanisms underlying this selectivity are not well understood. Previous studies of both visual and auditory neurons have suggested two general mechanisms for direction selectivity: (1) differential delays of excitatory inputs across the spatial/spectral receptive field and (2) spatial/spectral offset between excitatory and inhibitory inputs. In this study, we have examined the contributions of both mechanisms to FM direction selectivity in rat primary auditory cortex. The excitatory and inhibitory synaptic inputs to each cortical neuron were measured by in vivo whole-cell recording. The spectrotemporal receptive field of each type of inputs was mapped with random tone pips and compared with direction selectivity of the neuron measured with FM stimuli. We found that both the differential delay of the excitatory input and the spectral offset between excitation and inhibition are positively correlated with direction selectivity of the neuron. Thus, both synaptic mechanisms are likely to contribute to FM direction selectivity in the auditory cortex. Finally, direction selectivity measured from the spiking output is significantly stronger than that based on the subthreshold membrane potentials, indicating that the selectivity is further sharpened by the spike generation mechanism.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1618
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Ye, Chang-quan; Poo, Mu-ming; Dan, Yang; Zhang, Xiao-hui.Synaptic Mechanisms of Direction Selectivity in Primary Auditory Cortex,JOURNAL OF NEUROSCIENCE,2010,30(5):1861-1868
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