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Title: Expression of beta-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila
Author: Zhao, Xiao-Liang ; Wang, Wen-An ; Tan, Jiang-Xiu ; Huang, Jian-Kang ; Zhang, Xiao ; Zhang, Bao-Zhu ; Wang, Yu-Hang ; YangCheng, Han-Yu ; Zhu, Hong-Lian ; Sun, Xiao-Jiang ; null(黄福德)
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2010
Volume: 30, Issue:4, Pages:1512-1522
Keyword: LONG-TERM POTENTIATION ; IMPAIR SYNAPTIC PLASTICITY ; INTRANEURONAL-A-BETA ; ALZHEIMERS-DISEASE ; TRANSGENIC MICE ; PRECURSOR PROTEIN ; MITOCHONDRIAL DYSFUNCTION ; COGNITIVE DECLINE ; PLAQUE-FORMATION ; NEURODEGENERATIVE DISEASES
Subject: Neurosciences & Neurology
Corresponding Author: Huang, FD (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,fdhuang@ion.ac.cn
English Abstract: Alzheimer's disease (AD) is attributable to synapse dysfunction and loss, but the nature and progression of the presynaptic structural and functional changes in AD are essentially unknown. We expressed wild-type or arctic form of beta amyloid(1-42) (A beta) in a small group of neurons in the adult fly and performed extensive time course analysis of the function and structure of both axon and presynaptic terminals at the identified single-neuron level. A beta accumulated intracellularly and induced a range of age-dependent changes, including depletion of presynaptic mitochondria, slowdown of bi-directional transports of axonal mitochondria, decreased synaptic vesicles, increased large vacuoles, and elevated synaptic fatigue. These structural and functional synaptic changes correlated with age-dependent deficit in motor behavior. All these alterations were accelerated in flies expressing the arctic form of A beta. The depletion of presynaptic mitochondria was the earliest detected phenotype and was not caused by the change in axonal transport of mitochondria. Moreover, axonal mitochondria exhibited a dramatic reduction in number but a significant increase in size in aged A beta-expressing flies, indicating a global depletion of mitochondria in the neuron and an impairment of mitochondria fission. These results suggest that A beta accumulation depletes presynaptic and axonal mitochondria, leading to other presynaptic deficits.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1620
Appears in Collections:神经所(总)_期刊论文
神经退行性疾病研究小组_期刊论文

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Recommended Citation:
Zhao, Xiao-Liang; Wang, Wen-An; Tan, Jiang-Xiu; Huang, Jian-Kang; Zhang, Xiao; Zhang, Bao-Zhu; Wang, Yu-Hang; YangCheng, Han-Yu; Zhu, Hong-Lian; Sun, Xiao-Jiang; Huang, Fu-De.Expression of beta-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila,JOURNAL OF NEUROSCIENCE,2010,30(4):1512-1522
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