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Title: The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond
Author: null(仇子龙) ; Cheng, Ju
Source: NEUROSIGNALS
Issued Date: 2010
Volume: 18, Issue:2, Pages:72-81
Keyword: Calcium ; Transcription ; MeCP2 ; Copy number variations ; SPINOCEREBELLAR ATAXIA TYPE-1 ; UBIQUITIN-PROTEIN LIGASE ; COPY NUMBER VARIATION ; RETT-SYNDROME ; MOUSE MODEL ; ANGELMAN-SYNDROME ; TRANSCRIPTIONAL REPRESSION ; INTERSTITIAL DELETION ; SYNAPTIC-TRANSMISSION ; NEUROLOGICAL DISEASE
Subject: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology ; Neurosciences & Neurology
Corresponding Author: Qiu, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Yueyang Rd 320, Shanghai 200031, Peoples R China,zqiu@ion.ac.cn
English Abstract: During the last decade, autism spectrum disorders (ASD) have become the center of attention where several branches of modern biology unexpectedly meet, such as neural development, molecular biology, epigenetics, neurophysiology and psychiatry. This review will focus on the molecular mechanism by which calcium-dependent gene expression regulates brain development and how ASD may occur if this process is compromised. Specifically, the studies of the calcium-dependent transcriptional repressor MeCP2 gave us much insight about how abnormal development may lead to ASD. Most recently, studies about Ube3a, a critical component of the ubiquitination system enzyme, shed light on how neural activity regulates synapse function through the protein degradation pathway. Taken together, these studies suggest that ASD may be caused by the incapability of neurons to generate adaptive responses via regulating gene expression upon incoming activity. Copyright (C) 2010 S. Karger AG, Basel
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1622
Appears in Collections:神经所(总)_期刊论文
神经可塑性分子基础研究组_期刊论文

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Recommended Citation:
Qiu, Zilong; Cheng, Ju.The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond,NEUROSIGNALS,2010,18(2):72-81
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