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Title: An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons
Author: Hao, Jiang ; Wang, Xu-dong ; Dan, Yang ; null(蒲慕明) ; Zhang, Xiao-hui
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Issued Date: 2009
Volume: 106, Issue:51, Pages:21906-21911
Keyword: dendrite integration ; dendritic summation ; neuronal computation ; shunting inhibition ; synaptic physiology ; DENDRITIC TREE ; NEURAL-NETWORK ; CELLS ; HIPPOCAMPUS ; OSCILLATIONS ; TRANSMITTER ; PROPAGATION ; COMPUTATION ; INTEGRATION ; ACTIVATION
Subject: Science & Technology - Other Topics
Corresponding Author: Poo, MM (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,mpoo@berkeley.edu ; xhzhang@ion.ac.cn
English Abstract: Dendritic integration of excitatory and inhibitory inputs is critical for neuronal computation, but the underlying rules remain to be elucidated. Based on realistic modeling and experiments in rat hippocampal slices, we derived a simple arithmetic rule for spatial summation of concurrent excitatory glutamatergic inputs (E) and inhibitory GABAergic inputs (I). The somatic response can be well approximated as the sum of the excitatory postsynaptic potential (EPSP), the inhibitory postsynaptic potential (IPSP), and a nonlinear term proportional to their product (k*EPSP*IPSP), where the coefficient k reflects the strength of shunting effect. The k value shows a pronounced asymmetry in its dependence on E and I locations. For I on the dendritic trunk, k decays rapidly with E-I distance for proximal Es, but remains largely constant for distal Es, indicating a uniformly high shunting efficacy for all distal Es. For I on an oblique branch, the shunting effect is restricted mainly within the branch, with the same proximal/distal asymmetry. This asymmetry can be largely attributed to cable properties of the dendrite. Further modeling studies showed that this rule also applies to the integration of multiple coincident Es and Is. Thus, this arithmetic rule offers a simple analytical tool for studying E-I integration in pyramidal neurons that incorporates the location specificity of GABAergic shunting inhibition.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1623
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Hao, Jiang; Wang, Xu-dong; Dan, Yang; Poo, Mu-ming; Zhang, Xiao-hui.An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(51):21906-21911
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