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Title: Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus
Author: Chen, Min ; Chen, Qian ; Cheng, Xue-Wen ; Lu, Ting-Jia ; Liu, Han-Xing ; Jia, Jie-Min ; Zhang, Chi ; Xu, Li ; null(熊志奇)
Source: JOURNAL OF NEUROCHEMISTRY
Issued Date: 2009
Volume: 111, Issue:5, Pages:1094-1103
Keyword: global ischemia ; hippocampus ; neurodegeneration ; proteasome ; ubiquitination ; TRANSIENT CEREBRAL-ISCHEMIA ; PROTEIN AGGREGATION ; CORTICAL-NEURONS ; CA1 NEURONS ; MITOCHONDRIAL DYSFUNCTION ; DEGRADATION SIGNALS ; FOREBRAIN ISCHEMIA ; ZINC TOXICITY ; INDUCED DEATH ; NITRIC-OXIDE
Subject: Biochemistry & Molecular Biology ; Neurosciences & Neurology
Corresponding Author: Xiong, ZQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,xiongzhiqi@ion.ac.cn
English Abstract: Deposition of ubiquitinated protein aggregates is a hallmark of neurodegeneration in both acute neural injuries, such as stroke, and chronic conditions, such as Parkinson's disease, but the underlying mechanisms are poorly understood. In the present study, we examined the role of Zn2+ in ischemia-induced impairment of the ubiquitin-proteasome system in the CA1 region of rat hippocampus after transient global ischemia. We found that scavenging endogenous Zn2+ reduced ischemia-induced ubiquitin conjugation and free ubiquitin depletion. Furthermore, exposure to zinc chloride increased ubiquitination and inhibited proteasomal enzyme activity in cultured hippocampal neurons in a concentration- and time-dependent manner. Further studies of the underlying mechanisms showed that Zn2+-induced ubiquitination required p38 activation. These findings indicate that alterations in Zn2+ homeostasis impair the protein degradation pathway.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1627
Appears in Collections:神经所(总)_期刊论文
疾病神经生物学研究组_期刊论文

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Chen, Min; Chen, Qian; Cheng, Xue-Wen; Lu, Ting-Jia; Liu, Han-Xing; Jia, Jie-Min; Zhang, Chi; Xu, Li; Xiong, Zhi-Qi.Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus,JOURNAL OF NEUROCHEMISTRY,2009,111(5):1094-1103
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