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Title: Long-range retrograde spread of LTP and LTD from optic tectum to retina
Author: Du, Jiu-lin ; Wei, Hong-ping ; Wang, Zuo-ren ; Wong, Scott T. ; null(蒲慕明)
Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Issued Date: 2009
Volume: 106, Issue:45, Pages:18890-18896
Keyword: neural development ; retrograde signaling ; synaptic plasticity ; retinal ganglion cell ; PRESYNAPTIC NEURONAL EXCITABILITY ; DEVELOPING RETINOTECTAL SYSTEM ; REMODELING IN-VIVO ; TERM POTENTIATION ; NEUROTROPHIC FACTOR ; SYNAPTIC PLASTICITY ; LASTING POTENTIATION ; MAMMALIAN BRAIN ; NEURAL-NETWORKS ; VISUAL-SYSTEM
Subject: Science & Technology - Other Topics
Corresponding Author: Poo, MM (reprint author), Univ Calif Berkeley, Helen Wills Neurosci Inst, Dept Mol & Cell Biol, Div Neurobiol, Berkeley, CA 94720 USA,mpoo@berkeley.edu
English Abstract: Neural activity can induce persistent strengthening or weakening of synapses, known as long-term potentiation (LTP) or long-term depression (LTD), respectively. As potential cellular mechanisms underlying learning and memory, LTP and LTD are generally regarded as synapse-specific "imprints'' of activity, although there is evidence in vitro that LTP/LTD may spread to adjacent synapses. Here, we report that LTP and LTD induced in vivo at retinotectal synapses of Xenopus tadpoles undergo rapid long-range retrograde spread from the optic tectum to the retina, resulting in potentiation and depression of bipolar cell synapses on the dendrites of retinal ganglion cells, respectively. The retrograde spread of LTP and LTD required retrograde signaling initiated by brain-derived neurotrophic factor and nitric oxide in the tectum, respectively. Such bidirectional adjustment of the strength of input synapses in accordance to that of output synapses may serve to coordinate developmental refinement and learning functions of neural circuits.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1630
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Recommended Citation:
Du, Jiu-lin; Wei, Hong-ping; Wang, Zuo-ren; Wong, Scott T.; Poo, Mu-ming.Long-range retrograde spread of LTP and LTD from optic tectum to retina,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(45):18890-18896
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