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Title: Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila
Author: Li, Xinjian ; Yu, Feng ; Guo, Aike
Source: SLEEP
Issued Date: 2009
Volume: 32, Issue:11, Pages:1417-1424
Keyword: Drosophila ; sleep ; learning and memory ; cAMP ; slpD ; mushroom body ; MUSHROOM BODY ; RAT HIPPOCAMPUS ; REDUCED SLEEP ; REM-SLEEP ; CONSOLIDATION ; MELANOGASTER ; MAINTENANCE ; NEURONS ; STRESS ; BODIES
Subject: Neurosciences & Neurology
Corresponding Author: Guo, AK (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurosci, Shanghai 200031, Peoples R China,Hakguo@ion.ac.cn
English Abstract: Study Objectives: Sleep is crucial to memory consolidation in humans and other animals; however, the effect of insufficient sleep on subsequent learning and memory remains largely elusive. Design: Learning and memory after 1-day sleep deprivation (slpD) was evaluated using Pavlovian olfactory conditioning in Drosophila, and locomotor activity was measured using the Drosophila Activity Monitoring System in a 12:12 light-dark cycle. Results: We found that slpD specifically impaired 1-h memory in wild type Canton-S flies, and this effect could persist for at least 2 h. However, alternative stresses (heat stress, oxidative stress, starvation, and rotation stress) did not result in a similar effect and left the flies' memory intact. Mechanistic studies demonstrated that flies with either silenced transmission of the mushroom body (MB) during slpD or down-regulated cAMP levels in the MB demonstrated no slpD-induced 1-h memory impairment. Conclusion: We found that slpD specifically impaired 1-h memory in Drosophila, and either silencing of MB transmission during slpD or down-regulation of the cAMP level in the MB protected the flies from slpD-induced impairment.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1632
Appears in Collections:神经所(总)_期刊论文

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Li, Xinjian; Yu, Feng; Guo, Aike.Sleep Deprivation Specifically Impairs Short-term Olfactory Memory in Drosophila,SLEEP,2009,32(11):1417-1424
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