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Title: SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice
Author: Zhang, Xiaochang ; Lei, Kai ; Yuan, Xiaobing ; Wu, Xiaohui ; Zhuang, Yuan ; Xu, Tian ; Xu, Rener ; Han, Min
Source: NEURON
Issued Date: 2009
Volume: 64, Issue:2, Pages:173-187
Keyword: DREIFUSS MUSCULAR-DYSTROPHY ; CENTRAL-NERVOUS-SYSTEM ; MEMBRANE PROTEIN ; NEUROMUSCULAR-JUNCTION ; ACTIN CYTOSKELETON ; CELL POLARIZATION ; SKELETAL-MUSCLE ; ENVELOPE ; LIS1 ; DYNEIN
Subject: Neurosciences & Neurology
Corresponding Author: Xu, R (reprint author), Fudan Univ, Sch Life Sci, Inst Dev Biol & Mol Med, Shanghai 200433, Peoples R China,rener_xu@fudan.edu.cn ; mhan@colorado.edu
English Abstract: Nuclear movement is critical during neurogenesis and neuronal migration, which are fundamental for mammalian brain development. Although dynein, Lis1, and other cytoplasmic proteins are known for their roles in connecting microtubules to the nucleus during interkinetic nuclear migration (INM) and nucleokinesis, the factors connecting dynein/Lis1 to the nuclear envelope (NE) remain to be determined. We report here that the SUN-domain proteins SUM and SUN2 and the KASH-domain proteins Syne-1/Nesprin-1 and Syne-2/Nesprin-2 play critical roles in neurogenesis and neuronal migration in mice. We show that SUM and SUN2 redundantly form complexes with Syne-2 to mediate the centrosome-nucleus coupling during both INM and radial neuronal migration in the cerebral cortex. Syne-2 is connected to the centrosome through interactions with both dynein/dynactin and kinesin complexes. Syne-2 mutants also display severe defects in learning and memory. These results fill. an important gap in our understanding of the mechanism of nuclear movement during brain development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1633
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Zhang, Xiaochang; Lei, Kai; Yuan, Xiaobing; Wu, Xiaohui; Zhuang, Yuan; Xu, Tian; Xu, Rener; Han, Min.SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice,NEURON,2009,64(2):173-187
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