中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Critical role of TRPC6 channels in VEGF-mediated angiogenesis
Author: Ge, Ruiliang ; Tai, Yilin ; Sun, Yuanyuan ; Zhou, Kechun ; Yang, Shenglian ; Cheng, Tianlin ; Zou, Qifei ; Shen, Feng ; null(王以政)
Source: CANCER LETTERS
Issued Date: 2009
Volume: 283, Issue:1, Pages:43-51
Keyword: TRPC6 ; Angiogenesis ; VEGF ; Proliferation ; Tube formation ; ENDOTHELIAL GROWTH-FACTOR ; VASCULAR-PERMEABILITY FACTOR ; RECEPTOR POTENTIAL CHANNELS ; CELL LUNG-CANCER ; CATION CHANNEL ; TUMOR ANGIOGENESIS ; PLUS CARBOPLATIN ; EPITHELIAL-CELLS ; CA2+ ENTRY ; IN-VIVO
Subject: Oncology
Corresponding Author: Shen, F (reprint author), Mil Med Coll 2, Div Comprehens Treatment, Eastern Hepatobiliary Hosp, Shanghai 200438, Peoples R China,shenfengdfgd@yahoo.com.cn ; yzwang@ion.ac.cn
English Abstract: Intracellular Ca(2+) signaling plays critical roles in VEGF-mediated angiogenesis. Transient receptor potential canonical (TRPC) channel 6, a Ca(2+)-permeable non-selective cation channel, can be activated by VEGF. Here, we report that TRPC6 is important for VEGF-mediated angiogenesis. Inhibition of TRPC6 in human umbilical vein endothelial cells (HUVECs) by pharmacological or genetic approaches arrested HUVECs at G2/M phase and suppressed VEGF-induced HUVEC proliferation and tube formation. Furthermore, inhibition of TRPCs abolished VEGF-, but not FGF-induced angiogenesis in the chick embryo chorioallantoic membrane. These results suggest that TRPC6 plays an important role in VEGF-mediated angiogenesis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1640
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Ge-2009-Critical role of TRP.pdf(643KB)----开放获取View Download

Recommended Citation:
Ge, Ruiliang; Tai, Yilin; Sun, Yuanyuan; Zhou, Kechun; Yang, Shenglian; Cheng, Tianlin; Zou, Qifei; Shen, Feng; Wang, Yizheng.Critical role of TRPC6 channels in VEGF-mediated angiogenesis,CANCER LETTERS,2009,283(1):43-51
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ge, Ruiliang]'s Articles
[Tai, Yilin]'s Articles
[Sun, Yuanyuan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ge, Ruiliang]‘s Articles
[Tai, Yilin]‘s Articles
[Sun, Yuanyuan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Ge-2009-Critical role of TRP.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!