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Title: Znhit1 causes cell cycle arrest and down-regulates CDK6 expression
Author: Yang, Zhengmin ; Cao, Yonghao ; Zhu, Xiaoyan ; Huang, Ying ; Ding, Yuqiang ; Liu, Xiaolong
Source: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Issued Date: 2009
Volume: 386, Issue:1, Pages:146-152
Keyword: Zf-HIT domain ; Znhit1 ; Cell cycle arrest ; CDK6 ; T cell proliferation ; DEPENDENT KINASES ; PROTEIN ; NUCLEAR ; DIFFERENTIATION ; PROLIFERATION ; COACTIVATOR ; TRANSITION ; COMPLEXES ; CANCER ; DOMAIN
Subject: Biochemistry & Molecular Biology ; Biophysics
Corresponding Author: Liu, XL (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,liux@sibs.ac.cn
English Abstract: Cyclin-dependent kinase 6 (CDK6) is the key element of the D-type cyclin holoenzymes which has been found to function in the regulation of G1-phase of the cell cycle and is presumed to play important roles in T cell function. In this study, Znhit1, a member of a new zinc finger protein family defined by a conserved Zf-HIT domain, induced arrest in the G1-phase of the cell cycle in NIH/3T3 cells. Of the G1 cell cycle factors examined, the expression of CDK6 was found to be strongly down-regulated by Znhit1 via transcriptional repression. This effect may have correlations with the decreased acetylation level of histone H4 in the CDK6 promoter region. In addition, considering that CDK6 expression predominates in T cells, the negative regulatory role of Znhit1 in TCR-induced T cell proliferation was validated using transgenic mice. These findings identified Znhit1 as a CDK6 regulator that plays an important role in cell proliferation. (C) 2009 Elsevier Inc. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1648
Appears in Collections:神经所(总)_期刊论文

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Yang, Zhengmin; Cao, Yonghao; Zhu, Xiaoyan; Huang, Ying; Ding, Yuqiang; Liu, Xiaolong.Znhit1 causes cell cycle arrest and down-regulates CDK6 expression,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,386(1):146-152
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