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Title: Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
Author: Hu, Wenqin ; Tian, Cuiping ; Li, Tun ; Yang, Mingpo ; Hou, Han ; null(舒友生)
Source: NATURE NEUROSCIENCE
Issued Date: 2009
Volume: 12, Issue:8, Pages:996-U61
Keyword: NEOCORTICAL PYRAMIDAL NEURONS ; DEPENDENT SYNAPTIC PLASTICITY ; SODIUM-CHANNELS ; ION CHANNELS ; CELL-TYPE ; AXON ; SEGMENT ; ACTIVATION ; SPIKES ; MODEL
Subject: Neurosciences & Neurology
Corresponding Author: Shu, YS (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai, Peoples R China,shu@ion.ac.cn
English Abstract: The distal end of the axon initial segment (AIS) is the preferred site for action potential initiation in cortical pyramidal neurons because of its high Na+ channel density. However, it is not clear why action potentials are not initiated at the proximal AIS, which has a similarly high Na+ channel density. We found that low-threshold Na(v)1.6 and high-threshold Na(v)1.2 channels preferentially accumulate at the distal and proximal AIS, respectively, and have distinct functions in action potential initiation and backpropagation. Patch-clamp recording from the axon cut end of pyramidal neurons in the rat prefrontal cortex revealed a high density of Na+ current and a progressive reduction in the half-activation voltage (up to 14 mV) with increasing distance from the soma at the AIS. Further modeling studies and simultaneous somatic and axonal recordings showed that distal Na(v)1.6 promotes action potential initiation, whereas proximal Na(v)1.2 promotes its backpropagation to the soma.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1652
Appears in Collections:神经所(总)_期刊论文
神经网络功能研究组_期刊论文

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Recommended Citation:
Hu, Wenqin; Tian, Cuiping; Li, Tun; Yang, Mingpo; Hou, Han; Shu, Yousheng.Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation,NATURE NEUROSCIENCE,2009,12(8):996-U61
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