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Title: Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration
Author: Tong, Xiao-ping ; Li, Xiang-yao ; Zhou, Bing ; Shen, Wanhua ; Zhang, Zhi-jun ; Xu, Tian-Le(徐天乐) ; Duan, Shumin
Source: JOURNAL OF CELL BIOLOGY
Issued Date: 2009
Volume: 186, Issue:1, Pages:113-128
Keyword: OLIGODENDROCYTE PRECURSOR CELLS ; GIANT DEPOLARIZING POTENTIALS ; POSTNATAL SUBVENTRICULAR ZONE ; CENTRAL-NERVOUS-SYSTEM ; CNS WHITE-MATTER ; RAT OPTIC-NERVE ; NEURONAL MIGRATION ; MULTIPLE-SCLEROSIS ; ADHESION MOLECULE ; PROGENITOR CELLS
Subject: Cell Biology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn
English Abstract: NG2 cells originate from various brain regions and migrate to their destinations during early development. These cells express voltage-gated Na+ channels but fail to produce typical action potentials. The physiological role of Na+ channels in these cells is unclear. We found that GABA induces membrane depolarization and Ca2+ elevation in NG2 cells, a process requiring activation of GABA(A) receptors, Na+ channels, and Na+/Ca2+ exchangers (NCXs), but not Ca2+ channels. We have identified a persistent Na+ current in these cells that may underlie the GABA-induced pathway of prolonged Na+ elevation, which in turn triggers Ca2+ influx via NCXs. This unique Ca2+ signaling pathway is further shown to be involved in the migration of NG2 cells. Thus, GABAergic signaling mediated by sequential activation of GABA(A) receptors, noninactivating Na+ channels, and NCXs may play an important role in the development and function of NG2 glial cells in the brain.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1653
Appears in Collections:神经所(总)_期刊论文

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Tong, Xiao-ping; Li, Xiang-yao; Zhou, Bing; Shen, Wanhua; Zhang, Zhi-jun; Xu, Tian-le; Duan, Shumin.Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration,JOURNAL OF CELL BIOLOGY,2009,186(1):113-128
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