中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons
Author: Liao, Chun-yang ; Cui, Lin ; Zhou, Qun-fang ; Duan, Shu-min ; Jiang, Gui-bin
Source: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Issued Date: 2009
Volume: 27, Issue:3, Pages:338-344
Keyword: Perfluorooctane sulfonate (PFOS) ; Neurotoxicity ; Potassium channel ; Sodium channel ; Glutamate-activated current ; VENTRICULAR MYOCYTES ; PERFLUORINATED COMPOUNDS ; PERFLUOROALKYL ACIDS ; PFOA CONCENTRATIONS ; MASS-SPECTROMETRY ; NHANES 1999-2000 ; NATIONAL-HEALTH ; US POPULATION ; K+ CURRENT ; INHIBITION
Subject: Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
Corresponding Author: Jiang, GB (reprint author), Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, POB 2871, Beijing 100085, Peoples R China,gbjiang@rcees.ac.cn
English Abstract: Concern on an emerging persistent contaminant, perfluorooctane sulfonate (PFOS), is increasingly growing. Although the fate, transport. distribution and bioaccumulation of PFOS have been documented, its toxicological effects especially neurotoxicity remain largely unknown. In this study, the effects of PFOS on ion channels including potassium and sodium channels and exogenous glutamate-activated current in cultured rat hippocampal neurons were examined, based on whole-cell patch-clamp recording. PFOS markedly increased two subtypes of potassium currents, including transient outward current and delayed rectifier current, at doses over 10 mu M. PFOS did not affect the amplitude of sodium current at all administrated doses (1, 10 or 100 mu M) but clearly shifted the activation current-voltage curve toward negatively potential. Further. PFOS significantly altered the glutamate-activated current at all doses. Taken together these findings indicated that PFOS disturbs the neuronal physiological processes, which revealed the damage of this pollutant to nerve system and will be helpful for further exploration to its underlying mechanism. (C) 2009 Published by Elsevier B.V.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1661
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Liao-2009-Effects of perfluoro.pdf(655KB)----开放获取View Download

Recommended Citation:
Liao, Chun-yang; Cui, Lin; Zhou, Qun-fang; Duan, Shu-min; Jiang, Gui-bin.Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons,ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(3):338-344
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liao, Chun-yang]'s Articles
[Cui, Lin]'s Articles
[Zhou, Qun-fang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liao, Chun-yang]‘s Articles
[Cui, Lin]‘s Articles
[Zhou, Qun-fang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Liao-2009-Effects of perfluoro.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!