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Title: Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo
Author: Yin, Min ; Liu, Shuxi ; Yin, Yanqing ; Li, Sen ; Li, Zhihua ; Wu, Xuefei ; Zhang, Bo ; Ang, Siew-Lan ; Ding, Yuqiang ; null(周嘉伟)
Source: JOURNAL OF NEUROSCIENCE
Issued Date: 2009
Volume: 29, Issue:16, Pages:5170-5182
Keyword: RADIAL GLIA ; CELLS ; RAT ; DIFFERENTIATION ; SPECIFICATION ; NEUROGENIN-2 ; EXPRESSION ; PROJECTION ; MIGRATION ; STRIATUM
Subject: Neurosciences & Neurology
Corresponding Author: Zhou, JW (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,jwzhou@ion.ac.cn
English Abstract: Mesodiencephalic dopaminergic (mDA) neurons are critical for movement control and other physiological activities. However, the molecular mechanisms underlying their development are poorly understood. We aimed to establish the expression profiles of genes involved in this process and unravel genetic programs that control late development of mDA neurons. We compared genome-wide gene expression profiles of developing mouse ventral mesencephalon (VM) using microarrays. We identified a set of genes that show spatially and temporally restricted expression in the VM in an Ngn2 ( neurogenin 2)-dependent manner and are potentially important for mDA neuron development. Functional analysis on mice lacking the VM-specific gene early B-cell factor 1 (Ebf1) revealed that Ebf1 is essential for the terminal migration of mDA neurons in the substantia nigra pars compacta. Thus, we identified a set of VM-enriched genes that are important for mDA neuron development. Our analysis also provides a genetic framework for further investigation of the molecular mechanisms mediating mDA neuron development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1663
Appears in Collections:神经所(总)_期刊论文
基底神经节的发育与退行性疾病研究组_期刊论文

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Recommended Citation:
Yin, Min; Liu, Shuxi; Yin, Yanqing; Li, Sen; Li, Zhihua; Wu, Xuefei; Zhang, Bo; Ang, Siew-Lan; Ding, Yuqiang; Zhou, Jiawei.Ventral Mesencephalon-Enriched Genes That Regulate the Development of Dopaminergic Neurons In Vivo,JOURNAL OF NEUROSCIENCE,2009,29(16):5170-5182
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