中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010)
Author: Deng, J. ; Zhang, X. -L. ; Wang, J. -W. ; Teng, L. -L. ; Ge, J. ; Takeiviori, H. ; Xiong, Z. -Q. ; Zhou, Y.
Source: NEUROSCIENCE
Issued Date: 2009
Volume: 159, Issue:3, Pages:1023-1031
Keyword: TORC1 ; retinal ganglion cells ; Ca(2+) ; retinal ischemic injury ; ELEMENT-BINDING PROTEIN ; SENSITIVE COINCIDENCE DETECTOR ; ISCHEMIA-REPERFUSION INJURY ; MEDIATED GENE-EXPRESSION ; REGENERATIVE CAPACITY ; COACTIVATOR TORC2 ; IN-VIVO ; PHOSPHORYLATION ; ACTIVATION ; TRANSCRIPTION
Subject: Neurosciences & Neurology
Corresponding Author: Zhang, XL (reprint author), Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China,zhangxl2@mail.sysu.edu.cn ; yzhou@ion.ac.cn
English Abstract: Calcium- and cAMP-dependent activation of CREB and transcription of cAMP-responsive element (CRE)-target genes play critical roles in various physiological and pathological conditions. TORCs (transducers of regulated CREB) represent a new family of conserved CREB coactivators that function as intracellular calcium- and cAMP-sensitive coincidence detectors, controlling the kinetics of CRE-mediated responses and long-term potentiation of synaptic transmission. Here we examined the expression and activity-dependent translocaition of TORCs in adult retinal ganglion cells (RGCs), the primary target of acute retinal ischemic injury as well as chronic: retinal degenerative diseases. We found that both mRNAs of TORC1 and TORC2, but not TORC3, were enriched in adult rat retina. Comparing with TORC2, TORC1 protein was highly and selectively expressed in RGCs. At resting condition, TORC1 protein was localized in the cytoplasm but not nucleus of RGCs. Activation of N-methyl-D-aspartate (NMDA) receptors by intravitreous injection of NMDA or increase of cAMP signaling by administration of forskolin triggered nuclear accumulation of TORC1. Furthermore, transient retinal ischemic injury resulted in peri-nuclear and nuclear accumulation of TORC1 as well as transcription of BDNF in RGCs. Our results demonstrate that TORC1 is enriched in RGCs and its subcellular location could be regulated by Ca(2+) and cAMP, suggesting that manipulation of TORC1 activity may promote survival of IRGCs in some optic disease conditions. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1667
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
1-s2.0-S0306452209001717-main.pdf(903KB)----开放获取View Download

Recommended Citation:
Deng, J.; Zhang, X. -L.; Wang, J. -W.; Teng, L. -L.; Ge, J.; Takeiviori, H.; Xiong, Z. -Q.; Zhou, Y..EXPRESSION AND REGULATED NUCLEAR TRANSPORT OF TRANSDUCERS OF REGULATED CREB 1 IN RETINAL GANGLION CELLS (Retracted article. See vol. 169, pg. 950, 2010),NEUROSCIENCE,2009,159(3):1023-1031
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Deng, J.]'s Articles
[Zhang, X. -L.]'s Articles
[Wang, J. -W.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Deng, J.]‘s Articles
[Zhang, X. -L.]‘s Articles
[Wang, J. -W.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 1-s2.0-S0306452209001717-main.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!