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Title: DISTRIBUTION OF ACID-SENSING ION CHANNEL 3 IN THE RAT HYPOTHALAMUS
Author: Meng, Q. -Y. ; Wang, W. ; Chen, X. -N. ; Xu, T. -L. ; Zhou, J. -N.
Source: NEUROSCIENCE
Issued Date: 2009
Volume: 159, Issue:3, Pages:1126-1134
Keyword: ASIC3 ; hypothalamus ; RT-PCR ; Western blot ; immunohistochemistry ; CENTRAL-NERVOUS-SYSTEM ; GATED CATION CHANNEL ; SENSORY NEURONS ; MOLECULAR-CLONING ; NA+ CHANNEL ; EXPRESSION ; BRAIN ; LOCALIZATION ; FAMILY ; ASIC3
Subject: Neurosciences & Neurology
Corresponding Author: Zhou, JN (reprint author), Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol, Rd 433, Hefei 230027, Anhui, Peoples R China,jnzhou@ustc.edu.cn
English Abstract: Acid-sensing ion channels (ASICs), the members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily, are proton-gated voltage-insensitive cation channels. Six ASIC subunits have been identified and characterized in the mammalian nervous system so far. Of these subunits, ASIC3 has been shown to be predominantly expressed in the peripheral nervous system of rodents and implicated in mechnosensation, chemosensation and pain perception. Little is known on ASIC3 in the brain. We thus employed reverse transcription-polymerase chain reaction (RT-PCR) and Western blot to examine the expression of ASIC3 in various rat brain regions, including hippocampus, amygdala, caudate putamen, prefrontal cortex, and hypothalamus. Specific attention was paid to the distribution of ASIC3 in the hypothalamus of rats by using immunohistochemistry. ASIC3 immunoreactivity showed a widespread pattern throughout the hypothalamus, with the highest density in paraventricular nucleus, supraoptic nucleus, suprachiasmatic nucleus, arcuate nucleus, dorsomedial nucleus, median preoptic nucleus, ventromedial preoptic nucleus, and dorsal tuberomammillary nucleus. This study may contribute to the understanding of ASIC3 functions in the CNS. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1668
Appears in Collections:神经所(总)_期刊论文

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Meng, Q. -Y.; Wang, W.; Chen, X. -N.; Xu, T. -L.; Zhou, J. -N..DISTRIBUTION OF ACID-SENSING ION CHANNEL 3 IN THE RAT HYPOTHALAMUS,NEUROSCIENCE,2009,159(3):1126-1134
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