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Title: A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment
Author: Song, Ai-hong ; Wang, Dong ; Chen, Gang ; Li, Yuju ; Luo, Jianhong ; Duan, Shumin ; null(蒲慕明)
Source: CELL
Issued Date: 2009
Volume: 136, Issue:6, Pages:1148-1160
Keyword: HIPPOCAMPAL-NEURONS ; ANKYRIN-G ; MEMBRANE-PROTEINS ; GLUTAMATE RECEPTORS ; DIFFUSION BARRIER ; LATERAL DIFFUSION ; KINESIN ; TRAFFICKING ; MECHANISMS ; CHANNELS
Subject: Biochemistry & Molecular Biology ; Cell Biology
Corresponding Author: Duan, SM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, State Key Lab Neurobiol, Shanghai 200031, Peoples R China,shumin@ion.ac.cn ; mpoo@berkeley.edu
English Abstract: Distinct molecules are segregated into somatodendritic and axonal compartments of polarized neurons, but mechanisms underlying the development and maintenance of such segregation remain largely unclear. In cultured hippocampal neurons, we observed an ankyrin G-and F-actin-dependent structure that emerged in the cytoplasm of the axon initial segment (AIS) within 2 days after axon/dendrite differentiation, imposing a selective filter for diffusion of macromolecules and transport of vesicular carriers into the axon. Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B. Comparisons of transport rates between chimeric forms of KIF17 and KIF5B, with the motor and cargo-binding domains switched, and between KIF5 loaded with VAMP2 versus GluR2 suggest that axonal entry of vesicular carriers depends on the transport efficacy of KIF-cargo complexes. This selective AIS filtering may contribute to preferential trafficking and segregation of cellular components in polarized neurons.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1671
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

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Song, Ai-hong; Wang, Dong; Chen, Gang; Li, Yuju; Luo, Jianhong; Duan, Shumin; Poo, Mu-ming.A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment,CELL,2009,136(6):1148-1160
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