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Title: Transient receptor potential channel C3 contributes to the progression of human ovarian cancer
Author: Yang, S. L. ; Cao, Q. ; Zhou, K. C. ; Feng, Y. J. ; Wang, Y. Z.
Source: ONCOGENE
Issued Date: 2009
Volume: 28, Issue:10, Pages:1320-1328
Keyword: TRPC channels ; ovarian epithelium cancer ; proliferation ; Ca(2+)/calmodulin-dependent kinase II ; M phase ; CAPACITATIVE CA2+ ENTRY ; PROTEIN KINASE-II ; CELL-PROLIFERATION ; MAMMALIAN-CELLS ; TRPC3 CHANNELS ; CYTOSTATIC FACTOR ; EPITHELIAL-CELLS ; CALCIUM ; EXPRESSION ; ACTIVATION
Subject: Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
Corresponding Author: Wang, YZ (reprint author), Shanghai Inst Biol Sci, Inst Neurosci, Lab Neural Signal Transduct, State Key Lab Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: Ovarian cancer (OC) is the leading cause of death from gynecological malignancy. However, the mechanism by which OC develops remains largely unknown. Increases in cytosolic free Ca(2+) ([Ca(2+)](i)) can result in different physiological changes including cell growth, differentiation and death. The transient receptor potential (TRP) C channels are nonselective cation channels with permeability to Ca2(+). Here we report that TRPC3 channels promote human OC growth. The TRPC3 protein levels in human OC specimens were greatly increased than those in normal ovarian specimens. Downregulating TRPC3 expression in SKOV3 cells, a human OC cell line, led to reduction of proliferation, suppression in epidermal growth factor-induced Ca(2+) in flux, dephosphorylation of Cdc2 and CaMKII alpha and prolonged progression through M phase of these cells. Further, decreased the expression of TRPC3 suppressed the tumor formation generated by injecting SKOV3 cells in nude mice. Together, our results suggest that increased activity of TRPC3 channels is necessary for the development of OCs. Oncogene (2009) 28, 1320-1328; doi:10.1038/onc.2008.475; published online 19 January 2009
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1674
Appears in Collections:神经所(总)_期刊论文

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Yang, S. L.; Cao, Q.; Zhou, K. C.; Feng, Y. J.; Wang, Y. Z..Transient receptor potential channel C3 contributes to the progression of human ovarian cancer,ONCOGENE,2009,28(10):1320-1328
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