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Title: The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity
Author: null(王以政) ; Zhou, Kechun ; Yan, Dong ; Li, Mingtao ; null(王以政)
Source: JOURNAL OF NEUROCHEMISTRY
Issued Date: 2009
Volume: 108, Issue:4, Pages:909-919
Keyword: apoptosis ; cortical neuron ; Kv2 ; 1 ; membrane trafficking ; NMDA ; CELL-SURFACE MICRODOMAINS ; METHYL-D-ASPARTATE ; POTASSIUM CHANNEL ; K+ CHANNEL ; DEPENDENT TRAFFICKING ; SYNAPTIC PLASTICITY ; CORTICAL-NEURONS ; PROTEIN-KINASE ; PHOSPHORYLATION ; HIPPOCAMPAL
Subject: Biochemistry & Molecular Biology ; Neurosciences & Neurology
Corresponding Author: Wang, YZ (reprint author), Inst Neurosci, SIBS, State Key Lab Neurosci, Lab Neural Signal Transduct, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,yzwang@ion.ac.cn
English Abstract: Chronic loss of intracellular K(+) can induce neuronal apoptosis in pathological conditions. However, the mechanism by which the K(+) channels are regulated in this process remains largely unknown. Here, we report that the increased membrane expression of Kv2.1 proteins in cortical neurons deprived of serum, a condition known to induce K(+) loss, promotes neuronal apoptosis. The increase in I(K) current density and apoptosis in the neurons deprived of serum were inhibited by a dominant negative form of Kv2.1 and MK801, an antagonist to NMDA receptors. The membrane level of Kv2.1 and its interaction with SNAP25 were increased, whereas the Kv2.1 phosphorylation was inhibited in the neurons deprived of serum. Botulinum neurotoxin, an agent known to prevent formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex, suppressed the increase in I(K) current density. Together, these results suggest that NMDA receptor-dependent Kv2.1 membrane translocation is regulated by a soluble N-ethylmaleimide-sensitive factor attachment protein receptor-dependent vesicular trafficking mechanism and is responsible for neuronal cell death induced by chronic loss of K(+).
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1680
Appears in Collections:神经所(总)_期刊论文
神经信号转导研究组_期刊论文

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Recommended Citation:
Yao, Hailan; Zhou, Kechun; Yan, Dong; Li, Mingtao; Wang, Yizheng.The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity,JOURNAL OF NEUROCHEMISTRY,2009,108(4):909-919
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