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Title: Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control
Author: Xu, Tian-Le(徐天乐) ; Duan, Bo
Source: PROGRESS IN NEUROBIOLOGY
Issued Date: 2009
Volume: 87, Issue:3, Pages:171-180
Keyword: Acid-sensing ion channel ; Nociceptive ; Central sensitization ; Ca(2+) ; SPINAL DORSAL-HORN ; AMPA RECEPTOR SUBUNITS ; SENSORY NEURONS ; SYNAPTIC PLASTICITY ; INFLAMMATORY PAIN ; CAPSAICIN RECEPTOR ; NITRIC-OXIDE ; CENTRAL SENSITIZATION ; CHEMICAL NOCICEPTION ; GLUTAMATE RECEPTORS
Subject: Neurosciences & Neurology
Corresponding Author: Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
English Abstract: The development of chronic pain involves increased sensitivity of peripheral nociceptors and elevated neuronal activity in many regions of the central nervous system. Much of these changes are caused by the amplification of nociceptive signals resulting from the modulation and altered expression of specific ion channels and receptors in the central and peripheral nervous system. Understanding the processes by which these ion channels and receptors are regulated and how these mechanisms malfunction may lead to new treatments for chronic pain. Here we review the contribution of the Ca(2+)-permeable acid-sensing ion channel (ASIC(Ca)) in the development and persistence of chronic pain, and the potential underlying mechanisms. Accumulating evidence suggests that ASIC(Ca) represents an attractive new target for developing effective therapies for chronic pain. (c) 2009 Elsevier Ltd. All rights reserved.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1682
Appears in Collections:神经所(总)_期刊论文

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Recommended Citation:
Xu, Tian-Le; Duan, Bo.Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control,PROGRESS IN NEUROBIOLOGY,2009,87(3):171-180
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