中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses
Author: Xu, Chun ; Zhao, Man-xia ; null(蒲慕明) ; Zhang, Xiao-hui
Source: NATURE NEUROSCIENCE
Issued Date: 2008
Volume: 11, Issue:12, Pages:1410-1418
Keyword: LONG-TERM POTENTIATION ; INHIBITORY SYNAPTIC-TRANSMISSION ; HIPPOCAMPAL PYRAMIDAL CELLS ; NEONATAL-RAT HIPPOCAMPUS ; VISUAL-CORTEX ; REBOUND POTENTIATION ; CORTICAL-NEURONS ; KINASE-II ; INDUCTION ; MECHANISMS
Subject: Neurosciences & Neurology
Corresponding Author: Poo, MM (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,mpoo@berkeley.edu ; xhzhang@ion.ac.cn
English Abstract: Activity-induced long-term modification of glutamatergic synapses depends on the frequency of synaptic activation. We found that long-term modification of developing rat hippocampal GABAergic synapses that was induced by repetitive coincident pre- and postsynaptic spiking was also frequency dependent. Spiking at 20-50 Hz resulted in synaptic potentiation, whereas spiking at 5 Hz led to synaptic depression. The potentiation was abolished by blocking GABA(B) receptors (GABA(B)Rs), whereas the depression was independent of GABA(B)R activation and could be converted to potentiation by elevating GABA(B)R activity. The potentiation could be attributed to a local postsynaptic increase in Na(+)/K(+)/2Cl(-) co-transporter activity near activated synapses. The activity of postsynaptic Ca(2+)/calmodulin-dependent protein kinase II was necessary for long-term potentiation of these developing GABAergic synapses and its phosphorylation at Thr286 could be enhanced by activating GABA(B)Rs with baclofen. Together with our finding that activation of GABA(B)Rs is frequency dependent, these results indicate that postsynaptic GABA(B)R activation mediates frequency-dependent potentiation of developing GABAergic synapses.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1690
Appears in Collections:神经所(总)_期刊论文
神经可塑性研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Xu-2008-GABA(B) receptor act.pdf(631KB)----开放获取View Download

Recommended Citation:
Xu, Chun; Zhao, Man-xia; Poo, Mu-ming; Zhang, Xiao-hui.GABA(B) receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses,NATURE NEUROSCIENCE,2008,11(12):1410-1418
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Chun]'s Articles
[Zhao, Man-xia]'s Articles
[Poo, Mu-ming]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Chun]‘s Articles
[Zhao, Man-xia]‘s Articles
[Poo, Mu-ming]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Xu-2008-GABA(B) receptor act.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!