中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions
Author: Samson, Willis K. ; Zhang, Jian V. ; Avsian-Kretchmer, Orna ; Cui, Kai ; Yosten, Gina L. C. ; Klein, Cindy ; Lyu, Rong-Ming ; Wang, Yong Xiong ; Chen, Xiang Qun ; Yang, Jun ; Price, Christopher J. ; Hoyda, Ted D. ; Ferguson, Alastair V. ; Yuan, Xiao-bin ; Chang, Jaw Kang ; Hsueh, Aaron J. W.
Source: JOURNAL OF BIOLOGICAL CHEMISTRY
Issued Date: 2008
Volume: 283, Issue:46, Pages:31949-31959
Keyword: CENTRAL-NERVOUS-SYSTEM ; GROWTH-HORMONE ; FOOD-INTAKE ; C-FOS ; MOLECULAR-BIOLOGY ; BLOOD-PRESSURE ; SECRETION ; RECEPTORS ; PEPTIDE ; BRAIN
Subject: Biochemistry & Molecular Biology
Corresponding Author: Samson, WK (reprint author), St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA,samsonwk@slu.edu ; aaron.hsueh@stanford.edu
English Abstract: Somatostatin is important in the regulation of diverse neuroendocrine functions. Based on bioinformatic analyses of evolutionarily conserved sequences, we predicted another peptide hormone in pro-somatostatin and named it neuronostatin. Immuno-affinity purification allowed the sequencing of an amidated neuronostatin peptide of 13 residues from porcine tissues. In vivo treatment with neuronostatin induced c-Fos expression in gastrointestinal tissues, anterior pituitary, cerebellum, and hippocampus. In vitro treatment with neuronostatin promoted the migration of cerebellar granule cells and elicited direct depolarizing actions on paraventricular neurons in hypothalamic slices. In a gastric tumor cell line, neuronostatin induced c-Fos expression, stimulated SRE reporter activity, and promoted cell proliferation. Furthermore, intracerebroventricular treatment with neuronostatin increased blood pressure but suppressed food intake and water drinking. Our findings demonstrate diverse neuronal, neuroendocrine, and cardiovascular actions of a somatostatin gene-encoded hormone and provide the basis to investigate the physiological roles of this endogenously produced brain/gut peptide.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1691
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Samson-2008-Neuronostatin Encode.pdf(1182KB)----开放获取View Download

Recommended Citation:
Samson, Willis K.; Zhang, Jian V.; Avsian-Kretchmer, Orna; Cui, Kai; Yosten, Gina L. C.; Klein, Cindy; Lyu, Rong-Ming; Wang, Yong Xiong; Chen, Xiang Qun; Yang, Jun; Price, Christopher J.; Hoyda, Ted D.; Ferguson, Alastair V.; Yuan, Xiao-bin; Chang, Jaw Kang; Hsueh, Aaron J. W..Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions,JOURNAL OF BIOLOGICAL CHEMISTRY,2008,283(46):31949-31959
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Samson, Willis K.]'s Articles
[Zhang, Jian V.]'s Articles
[Avsian-Kretchmer, Orna]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Samson, Willis K.]‘s Articles
[Zhang, Jian V.]‘s Articles
[Avsian-Kretchmer, Orna]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Samson-2008-Neuronostatin Encode.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!