中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain
Author: Shi, Ming ; Guo, Chao ; Dai, Jin-Xia ; Ding, Yu-Qiang
Source: MOLECULAR AND CELLULAR NEUROSCIENCE
Issued Date: 2008
Volume: 39, Issue:4, Pages:529-538
Keyword: DCC ; Netrin ; Locus coeruleus ; Tangential migration ; Alar plate ; Rhombomere 1 ; Development ; AXON GUIDANCE ; COLORECTAL-CANCER ; SEROTONERGIC NEURONS ; NERVOUS-SYSTEM ; SPINAL-CORD ; NETRIN RECEPTOR ; SENSORY NEURONS ; GENE-PRODUCT ; PROTEIN ; DIFFERENTIATION
Subject: Neurosciences & Neurology
Corresponding Author: Ding, YQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn
English Abstract: The tangential migration from the dorsal rhombomere (r) 1 to the dorsolateral pontine tegmentum is a crucial event in the development of locus coeruleus (LC), but the molecular mechanisms underlying the migration are not well Understood. We show that the Netrin receptor DCC is expressed in LC neurons and is required for their tangential migration. In DCC(-/-) embryos, fate determination of LC neurons appeared normal but tangential migration failed to initiate properly. Although many LC neurons eventually reached the a Substantial number of LC dorsolateral pontine tegmentum in DCC(-/-) embryos at late embryonic stages, neurons were abnormally distributed in the rostral pons and cerebellum. In DCC(kanga) mice that lack the intracellular P3 domain of DCC, these defects were not observed. In addition, although Unc5h3, another Netrin receptor, was expressed in the dorsal r1, Unc5h3(-/-) mice exhibited the normal LC morphology and gene expression profiles in the LC compared with wild-type mice. Thus, our findings demonstrate that DCC is a key regulator of tangential migration of LC neurons during the embryonic development. (C) 2008 Published by Elsevier Inc.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1694
Appears in Collections:神经所(总)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Shi-2008-DCC is required for.pdf(9509KB)----开放获取View Download

Recommended Citation:
Shi, Ming; Guo, Chao; Dai, Jin-Xia; Ding, Yu-Qiang.DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain,MOLECULAR AND CELLULAR NEUROSCIENCE,2008,39(4):529-538
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Ming]'s Articles
[Guo, Chao]'s Articles
[Dai, Jin-Xia]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Ming]‘s Articles
[Guo, Chao]‘s Articles
[Dai, Jin-Xia]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Shi-2008-DCC is required for.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!