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Title: Actin Filament Assembly by Myristoylated, Alanine-rich C Kinase Substrate-Phosphatidylinositol-4,5-diphosphate Signaling Is Critical for Dendrite Branching
Author: Li, Haimin ; Chen, Gang ; Zhou, Bing ; Duan, Shumin
Source: MOLECULAR BIOLOGY OF THE CELL
Issued Date: 2008
Volume: 19, Issue:11, Pages:4804-4813
Keyword: RAT-BRAIN ; HIPPOCAMPAL-NEURONS ; MARCKS ; SUBSTRATE ; PROTEIN ; DYNAMICS ; ADHESION ; PIP2 ; ELECTROPORATION ; MORPHOGENESIS
Subject: Cell Biology
Corresponding Author: Duan, S (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China,shumin@ion.ac.cn
English Abstract: Dendrites undergo extensive growth and branching at early stages, but relatively little is known about the molecular mechanisms underlying these processes. Here, we show that increasing the level of myristoylated, alanine-rich C kinase substrate ( MARCKS), a prominent substrate of protein kinase C and a phosphatidylinositol-4,5-diphosphate [PI(4,5)P2] sequestration protein highly expressed in the brain, enhanced branching and growth of dendrites both in vitro and in vivo. Conversely, knockdown of endogenous MARCKS by RNA interference reduced dendritic arborization. Results from expression of different mutants indicated that membrane binding is essential for MARCKS-induced dendritic morphogenesis. Furthermore, MARCKS increased the number and length of filamentous actin-based filopodia along neurites, as well as the motility of filopodia, in a PI(4,5)P2-dependent manner. Time-lapse imaging showed that MARCKS increased frequency of filopodia initiation but did not affect filopodia longevity, suggesting that MARCKS may increase dendritic branching through its action on filopodia initiation. These findings demonstrate a critical role for MARCKS PI( 4,5) P2 signaling in regulating dendrite development.
Indexed Type: sci
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1695
Appears in Collections:神经所(总)_期刊论文

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Li, Haimin; Chen, Gang; Zhou, Bing; Duan, Shumin.Actin Filament Assembly by Myristoylated, Alanine-rich C Kinase Substrate-Phosphatidylinositol-4,5-diphosphate Signaling Is Critical for Dendrite Branching,MOLECULAR BIOLOGY OF THE CELL,2008,19(11):4804-4813
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