中国科学院上海生命科学研究院神经科学研究所机构知识库
Advanced  
SIBS OpenIR  > 神经所(总)  > 期刊论文
Title: A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol
Author: Zhang, Xiao-Bing ; Jiang, Peng ; Gong, Neng ; Hu, Xiao-Ling ; Fei, Da ; null(熊志奇) ; Xu, Lin ; Xu, Tian-Le(徐天乐)
Source: PLOS ONE
Issued Date: 2008
Volume: 3, Issue:10, Pages:e3386-e3387
Subject: Life Sciences & Biomedicine - Other Topics
Corresponding Author: Zhang, XB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,tlxu@ion.ac.cn
English Abstract: Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons. Although behavioral studies have implicated menthol actions in the brain, no direct central target of menthol has been identified. Here we show that menthol reduces the excitation of rat hippocampal neurons in culture and suppresses the epileptic activity induced by pentylenetetrazole injection and electrical kindling in vivo. We found menthol not only enhanced the currents induced by low concentrations of GABA but also directly activated GABA(A) receptor (GABA(A)R) in hippocampal neurons in culture. Furthermore, in the CA1 region of rat hippocampal slices, menthol enhanced tonic GABAergic inhibition although phasic GABAergic inhibition was unaffected. Finally, the structure-effect relationship of menthol indicated that hydroxyl plays a critical role in menthol enhancement of tonic GABA(A)R. Our results thus reveal a novel cellular mechanism that may underlie the ambivalent perception and psychophysical effects of menthol and underscore the importance of tonic inhibition by GABA(A)Rs in regulating neuronal activity.
Indexed Type: SCI
Language: 英语
Content Type: 期刊论文
URI: http://ir.sibs.ac.cn/handle/331001/1696
Appears in Collections:神经所(总)_期刊论文
疾病神经生物学研究组_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
pone.0003386.pdf(632KB)----开放获取View Download

Recommended Citation:
Zhang, Xiao-Bing; Jiang, Peng; Gong, Neng; Hu, Xiao-Ling; Fei, Da; Xiong, Zhi-Qi; Xu, Lin; Xu, Tian-Le.A-Type GABA Receptor as a Central Target of TRPM8 Agonist Menthol,PLOS ONE,2008,3(10):e3386-e3387
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Xiao-Bing]'s Articles
[Jiang, Peng]'s Articles
[Gong, Neng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Xiao-Bing]‘s Articles
[Jiang, Peng]‘s Articles
[Gong, Neng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: pone.0003386.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!